METTL16-dependent miR-146b-5p m6A modification remodeling sensitize NSCLC to osimertinib via activating PI3K/AKT signaling

METTL16-dependent miR-146b-5p m6A modification remodeling sensitize NSCLC to osimertinib via activating PI3K/AKT signaling

Abstract Background Non-small-cell lung cancer (NSCLC) is one of the most common malignant tumors, with poor prognosis and increasing osimertinib therapy resistance. Revealing mechanisms of NSCLC progression and therapy resistance remains critical. The aim of this study was to elucidate the molecula...

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Bibliographic Details
Main Authors: Hongyang Sang, Jinlong Liu, Xifang Chen, Yingou Zeng
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
NSCLC
Proliferation
miR-146b-5p
PI3K/AKT
Osimertinib resistance
Online Access:https://doi.org/10.1186/s12885-025-14041-y
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