Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation
An 8-year-old male pug with a 12-month history of a progressive nonpainful mass on the left cornea was evaluated. Ocular examination showed a severe bilateral keratoconjunctivitis sicca, pigmentary keratitis, and an exophytic irregular pink mass occupying approximately 75% of the total corneal surfa...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Veterinary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/596593 |
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| author | Giovanni Barsotti Lorenzo Ressel Riccardo Finotello Veronica Marchetti Francesca Millanta |
| author_facet | Giovanni Barsotti Lorenzo Ressel Riccardo Finotello Veronica Marchetti Francesca Millanta |
| author_sort | Giovanni Barsotti |
| collection | DOAJ |
| description | An 8-year-old male pug with a 12-month history of a progressive nonpainful mass on the left cornea was evaluated. Ocular examination showed a severe bilateral keratoconjunctivitis sicca, pigmentary keratitis, and an exophytic irregular pink mass occupying approximately 75% of the total corneal surface of the left eye. A squamous cell carcinoma (SCC) was suspected on cytology, and clinical investigations showed no evidence of metastases. A transpalpebral enucleation was therefore performed, and the diagnosis of SCC was confirmed on histopathology. Immunohistochemical investigations showed that the neoplastic cells were pan-cytokeratin positive and vimentin negative. Additionally, nuclei immunoreactive to Ki-67 antigen were detected. Tumor cells were also negative to p53. Immunoreactivity to COX-2 was found in less than 10% of the neoplastic cells. No adjuvant therapies were instituted, and no evidence of local recurrence or distance metastasis was identified during the 24-month follow-up period. |
| format | Article |
| id | doaj-art-fbdf1b486e3e4ebdb672cc8f4e72a603 |
| institution | OA Journals |
| issn | 2090-7001 2090-701X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Veterinary Medicine |
| spelling | doaj-art-fbdf1b486e3e4ebdb672cc8f4e72a6032025-08-20T02:22:56ZengWileyCase Reports in Veterinary Medicine2090-70012090-701X2012-01-01201210.1155/2012/596593596593Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological EvaluationGiovanni Barsotti0Lorenzo Ressel1Riccardo Finotello2Veronica Marchetti3Francesca Millanta4Department of Veterinary Clinics, Faculty of Veterinary Medicine, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Animal Pathology, Faculty of Veterinary Medicine, University of Pisa, Delle Piagge 2 Avenue, 56100 Pisa, ItalySmall Animal Teaching Hospital, University of Liverpool, Leahurst, Liverpool, Leahurst Campus Chester High Road, Neston, Wirral CH64 7TE, UKDepartment of Veterinary Clinics, Faculty of Veterinary Medicine, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Animal Pathology, Faculty of Veterinary Medicine, University of Pisa, Delle Piagge 2 Avenue, 56100 Pisa, ItalyAn 8-year-old male pug with a 12-month history of a progressive nonpainful mass on the left cornea was evaluated. Ocular examination showed a severe bilateral keratoconjunctivitis sicca, pigmentary keratitis, and an exophytic irregular pink mass occupying approximately 75% of the total corneal surface of the left eye. A squamous cell carcinoma (SCC) was suspected on cytology, and clinical investigations showed no evidence of metastases. A transpalpebral enucleation was therefore performed, and the diagnosis of SCC was confirmed on histopathology. Immunohistochemical investigations showed that the neoplastic cells were pan-cytokeratin positive and vimentin negative. Additionally, nuclei immunoreactive to Ki-67 antigen were detected. Tumor cells were also negative to p53. Immunoreactivity to COX-2 was found in less than 10% of the neoplastic cells. No adjuvant therapies were instituted, and no evidence of local recurrence or distance metastasis was identified during the 24-month follow-up period.http://dx.doi.org/10.1155/2012/596593 |
| spellingShingle | Giovanni Barsotti Lorenzo Ressel Riccardo Finotello Veronica Marchetti Francesca Millanta Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation Case Reports in Veterinary Medicine |
| title | Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation |
| title_full | Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation |
| title_fullStr | Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation |
| title_full_unstemmed | Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation |
| title_short | Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation |
| title_sort | primary corneal squamous cell carcinoma in a dog clinical and histopathological evaluation |
| url | http://dx.doi.org/10.1155/2012/596593 |
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