Peripheral EBV antigen-specific T cell is dysfunctional in Epstein–Barr virus positive diffuse large B-cell lymphoma

Peripheral EBV antigen-specific T cell is dysfunctional in Epstein–Barr virus positive diffuse large B-cell lymphoma

Abstract EBV-positive diffuse large B-cell lymphoma (EBV + DLBCL) is associated with poor prognosis, possibly due to the capacity of EBV to dampen host anti-tumor immunity. Patients’ peripheral EBV antigen-specific T lymphocytes may be functional deficiency. This study investigated the mechanisms un...

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Bibliographic Details
Main Authors: Liang Gao, Lihong Wang, Chao Xue, Xinan Cen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
EBV-positive DLBCL
T cell dysfunction
T cell exhaustion
T cell senescence
Online Access:https://doi.org/10.1186/s12885-025-14723-7
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