Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis
SCORring atopic dermatitis (SCORAD) is widely used to assess the severity of atopic eczema, but score systems based on the entire body may be limited in effective monitoring and intervention. It is crucial to monitor moisture levels in each affected body part, but empirical research is still lacking...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/drp/2376970 |
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| author | Bo Yeon Kwon Dohyeong Kim Kyungmin Shim Cindy Nguyen Hee Chul Lee Daeshik Kang Hohyun Kim SungChul Seo |
| author_facet | Bo Yeon Kwon Dohyeong Kim Kyungmin Shim Cindy Nguyen Hee Chul Lee Daeshik Kang Hohyun Kim SungChul Seo |
| author_sort | Bo Yeon Kwon |
| collection | DOAJ |
| description | SCORring atopic dermatitis (SCORAD) is widely used to assess the severity of atopic eczema, but score systems based on the entire body may be limited in effective monitoring and intervention. It is crucial to monitor moisture levels in each affected body part, but empirical research is still lacking. The objective of this study was to analyze the levels of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in atopic dermatitis (AD) patients, focusing on the presence and location of atopic lesions at different body sites. The levels of TEWL and SCH were measured using the AF200 AquaFlux and the Corneometer, respectively, at 15 body sites. 98 children under the age of 10 were measured, including 83 AD patients and 15 in the control group. Patients were also assessed with SCORAD and for the presence of atopic lesions at each body site. 58.7% of AD patients had lesions in the antecubital fossa and popliteal fossa, with corresponding low SCH levels and high TEWL in the upper body. The differences in TEWL between the control group and AD patients were confirmed significant in the neck and antecubital fossa regions, while differences in SCH were identified in the face, antecubital fossa, and popliteal fossa regions. A higher TEWL was found among AD patients with atopic lesions in the face and ankle. This study suggests that continuous monitoring of SCH and TEWL levels at specific body sites can provide insights into identifying vulnerable body areas to AD and supplement the SCORAD system for more effective clinical intervention and prevention strategies. |
| format | Article |
| id | doaj-art-fbd3a8ac377e4ba58bcc7bc8124e966a |
| institution | Kabale University |
| issn | 1687-6113 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-fbd3a8ac377e4ba58bcc7bc8124e966a2025-01-21T00:00:06ZengWileyDermatology Research and Practice1687-61132025-01-01202510.1155/drp/2376970Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic DermatitisBo Yeon Kwon0Dohyeong Kim1Kyungmin Shim2Cindy Nguyen3Hee Chul Lee4Daeshik Kang5Hohyun Kim6SungChul Seo7The Institute for Environmental Health and SafetySchool of EconomicThe Institute for Environmental Health and SafetySchool of EconomicThe Samsung Kids Pediatric Adolescent Clinic CenterDepartment of Mechanical EngineeringDepartment of Nano, Chemical and Biological EngineeringThe Institute for Environmental Health and SafetySCORring atopic dermatitis (SCORAD) is widely used to assess the severity of atopic eczema, but score systems based on the entire body may be limited in effective monitoring and intervention. It is crucial to monitor moisture levels in each affected body part, but empirical research is still lacking. The objective of this study was to analyze the levels of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in atopic dermatitis (AD) patients, focusing on the presence and location of atopic lesions at different body sites. The levels of TEWL and SCH were measured using the AF200 AquaFlux and the Corneometer, respectively, at 15 body sites. 98 children under the age of 10 were measured, including 83 AD patients and 15 in the control group. Patients were also assessed with SCORAD and for the presence of atopic lesions at each body site. 58.7% of AD patients had lesions in the antecubital fossa and popliteal fossa, with corresponding low SCH levels and high TEWL in the upper body. The differences in TEWL between the control group and AD patients were confirmed significant in the neck and antecubital fossa regions, while differences in SCH were identified in the face, antecubital fossa, and popliteal fossa regions. A higher TEWL was found among AD patients with atopic lesions in the face and ankle. This study suggests that continuous monitoring of SCH and TEWL levels at specific body sites can provide insights into identifying vulnerable body areas to AD and supplement the SCORAD system for more effective clinical intervention and prevention strategies.http://dx.doi.org/10.1155/drp/2376970 |
| spellingShingle | Bo Yeon Kwon Dohyeong Kim Kyungmin Shim Cindy Nguyen Hee Chul Lee Daeshik Kang Hohyun Kim SungChul Seo Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis Dermatology Research and Practice |
| title | Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis |
| title_full | Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis |
| title_fullStr | Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis |
| title_full_unstemmed | Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis |
| title_short | Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis |
| title_sort | area specific assessment of stratum corneum hydration and transepidermal water loss in pediatric patients with atopic dermatitis |
| url | http://dx.doi.org/10.1155/drp/2376970 |
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