Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1
Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1 (HSV-1) was done on Vero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Mo...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2018-03-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016301707 |
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| author | Sayed A. El-Toumy Josline Y. Salib Walaa A. El-Kashak Christel Marty Gilles Bedoux Nathalie Bourgougnon |
| author_facet | Sayed A. El-Toumy Josline Y. Salib Walaa A. El-Kashak Christel Marty Gilles Bedoux Nathalie Bourgougnon |
| author_sort | Sayed A. El-Toumy |
| collection | DOAJ |
| description | Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1 (HSV-1) was done on Vero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Morus alba (Moraceae) showed potent anti-herpetic activity and six other extracts showed moderate inhibition. In contrast, a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid compounds. The antiviral activity of the isolated compounds was also examined, among which seven pure compounds namely; 7-galloyl catechin, gallic acid, kaempferol 3-O-β-(6″-O-galloyl)-glucopyranoside, quercetin 3-O-β-(6″-O-galloyl)-glucopyranoside, curcumin, quercetin and kaempferol exhibited significant inhibition. Keywords: Egyptian plants, Anti-HSV-1, Polyphenols, Vero cell |
| format | Article |
| id | doaj-art-fbd06bac122446bbab90dc012dcc4954 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-fbd06bac122446bbab90dc012dcc49542025-02-03T10:41:29ZengTsinghua University PressFood Science and Human Wellness2213-45302018-03-017191101Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1Sayed A. El-Toumy0Josline Y. Salib1Walaa A. El-Kashak2Christel Marty3Gilles Bedoux4Nathalie Bourgougnon5Chemistry of Tannins Department, National Research Centre, Dokki, 12622 Cairo, EgyptChemistry of Tannins Department, National Research Centre, Dokki, 12622 Cairo, Egypt; Corresponding author at: Chemistry of Tannins Department, National Research Centre, Dokki, 12622 Cairo, Egypt.Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622 Cairo, Egypt,Centre de Recherché et d’enseignement Yves Coppens, Campus de Tohannic, BP 573, 56017 Vannes, FranceCentre de Recherché et d’enseignement Yves Coppens, Campus de Tohannic, BP 573, 56017 Vannes, FranceCentre de Recherché et d’enseignement Yves Coppens, Campus de Tohannic, BP 573, 56017 Vannes, FranceEvaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1 (HSV-1) was done on Vero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Morus alba (Moraceae) showed potent anti-herpetic activity and six other extracts showed moderate inhibition. In contrast, a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid compounds. The antiviral activity of the isolated compounds was also examined, among which seven pure compounds namely; 7-galloyl catechin, gallic acid, kaempferol 3-O-β-(6″-O-galloyl)-glucopyranoside, quercetin 3-O-β-(6″-O-galloyl)-glucopyranoside, curcumin, quercetin and kaempferol exhibited significant inhibition. Keywords: Egyptian plants, Anti-HSV-1, Polyphenols, Vero cellhttp://www.sciencedirect.com/science/article/pii/S2213453016301707 |
| spellingShingle | Sayed A. El-Toumy Josline Y. Salib Walaa A. El-Kashak Christel Marty Gilles Bedoux Nathalie Bourgougnon Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 Food Science and Human Wellness |
| title | Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 |
| title_full | Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 |
| title_fullStr | Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 |
| title_full_unstemmed | Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 |
| title_short | Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 |
| title_sort | antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1 |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016301707 |
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