Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally
Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in maternal-fetal medicine, despite advancements in prevention and management. HDFN occurs when maternal alloimmunization leads to the production of immunoglobulin G (IgG) antibodies that cross the placenta and trigger f...
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Galenos Publishing House
2024-11-01
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| Series: | Caucasian Medical Journal |
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| Online Access: | https://caucasianmedj.com/articles/successful-management-of-hemolytic-anemia-due-to-rh-immunization-diagnosed-antenatally/doi/cmj.galenos.2024.64936 |
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| author | Sevinch Mahmudova Gulnar Elizade Nezrin Hesenli Turab Janbakhishov Sarkhan Elbayiyev |
| author_facet | Sevinch Mahmudova Gulnar Elizade Nezrin Hesenli Turab Janbakhishov Sarkhan Elbayiyev |
| author_sort | Sevinch Mahmudova |
| collection | DOAJ |
| description | Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in maternal-fetal medicine, despite advancements in prevention and management. HDFN occurs when maternal alloimmunization leads to the production of immunoglobulin G (IgG) antibodies that cross the placenta and trigger fetal red blood cell hemolysis. Severe HDFN can cause hydrops fetalis and fetal death if left untreated, whereas survivors often face complications like neonatal anemia and hyperbilirubinemia, potentially causing kernicterus. A 42-year-old Rhesus (Rh)-negative woman with Rh-positive fetal anemia underwent intrauterine transfusions at 23 and 29 week of gestation. The fetus received Rh-negative donor blood during cordocentesis, which led to improvement in hemoglobin levels and normalization of Doppler parameters. Delivery at 34 weeks was via cesarean section because of premature membrane rupture. Postnatal management included exchange transfusion, phototherapy, and Ig therapy, resulting in stabilized hemoglobin and bilirubin levels. This case highlights the critical role of antenatal and postnatal interventions in managing severe HDFN. Regular monitoring and timely intervention, including Doppler ultrasound for anemia assessment and transfusion strategies, can significantly improve outcomes for high-risk neonates. |
| format | Article |
| id | doaj-art-fbcb35c6f8524556887b262db2f89169 |
| institution | Kabale University |
| issn | 2980-1818 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Caucasian Medical Journal |
| spelling | doaj-art-fbcb35c6f8524556887b262db2f891692025-01-20T07:42:18ZengGalenos Publishing HouseCaucasian Medical Journal2980-18182024-11-0123404110.4274/cmj.galenos.2024.64936Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed AntenatallySevinch Mahmudova0https://orcid.org/0009-0001-5313-9482Gulnar Elizade1https://orcid.org/0009-0006-3049-2570Nezrin Hesenli2https://orcid.org/0009-0003-4522-055XTurab Janbakhishov3https://orcid.org/0009-0005-8611-1135Sarkhan Elbayiyev4https://orcid.org/0000-0002-2113-5591Azerbaijan Medical University Department of Educational Surgery, Clinic of Neonatology, Baku, AzerbaijanAzerbaijan Medical University Department of Educational Surgery, Clinic of Neonatology, Baku, AzerbaijanAzerbaijan Medical University Department of Educational Surgery, Clinic of Neonatology, Baku, AzerbaijanAzerbaijan Medical University Department of Educational Surgery, Clinic of Neonatology, Baku, AzerbaijanAzerbaijan Medical University Department of Educational Surgery, Clinic of Neonatology, Baku, AzerbaijanHemolytic disease of the fetus and newborn (HDFN) remains a significant concern in maternal-fetal medicine, despite advancements in prevention and management. HDFN occurs when maternal alloimmunization leads to the production of immunoglobulin G (IgG) antibodies that cross the placenta and trigger fetal red blood cell hemolysis. Severe HDFN can cause hydrops fetalis and fetal death if left untreated, whereas survivors often face complications like neonatal anemia and hyperbilirubinemia, potentially causing kernicterus. A 42-year-old Rhesus (Rh)-negative woman with Rh-positive fetal anemia underwent intrauterine transfusions at 23 and 29 week of gestation. The fetus received Rh-negative donor blood during cordocentesis, which led to improvement in hemoglobin levels and normalization of Doppler parameters. Delivery at 34 weeks was via cesarean section because of premature membrane rupture. Postnatal management included exchange transfusion, phototherapy, and Ig therapy, resulting in stabilized hemoglobin and bilirubin levels. This case highlights the critical role of antenatal and postnatal interventions in managing severe HDFN. Regular monitoring and timely intervention, including Doppler ultrasound for anemia assessment and transfusion strategies, can significantly improve outcomes for high-risk neonates.https://caucasianmedj.com/articles/successful-management-of-hemolytic-anemia-due-to-rh-immunization-diagnosed-antenatally/doi/cmj.galenos.2024.64936rhesusnewbornanemia |
| spellingShingle | Sevinch Mahmudova Gulnar Elizade Nezrin Hesenli Turab Janbakhishov Sarkhan Elbayiyev Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally Caucasian Medical Journal rhesus newborn anemia |
| title | Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally |
| title_full | Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally |
| title_fullStr | Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally |
| title_full_unstemmed | Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally |
| title_short | Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally |
| title_sort | successful management of hemolytic anemia due to rh immunization diagnosed antenatally |
| topic | rhesus newborn anemia |
| url | https://caucasianmedj.com/articles/successful-management-of-hemolytic-anemia-due-to-rh-immunization-diagnosed-antenatally/doi/cmj.galenos.2024.64936 |
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