Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight
Primary Sjogren's syndrome (pSS) is a prevalent disease in rheumatology and immunology. Anxiety, depression, and other mood disorders are pervasive across diverse sectors of society. Recent theories on the gut-brain axis have elucidated that the gut microbiota considered the second brain of hum...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004256 |
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| author | Ying Zhu Kaiyuan Zhang Ziyue Luo Yu Song Xinchang Wang |
| author_facet | Ying Zhu Kaiyuan Zhang Ziyue Luo Yu Song Xinchang Wang |
| author_sort | Ying Zhu |
| collection | DOAJ |
| description | Primary Sjogren's syndrome (pSS) is a prevalent disease in rheumatology and immunology. Anxiety, depression, and other mood disorders are pervasive across diverse sectors of society. Recent theories on the gut-brain axis have elucidated that the gut microbiota considered the second brain of humans, can modulate the central nervous system and behavior by mediating bidirectional response systems, including immunity, vagus nerve, and neuroendocrine pathways. This article reviews recent advancements that explore the mechanism between gut microbiota and emotional disorders in pSS. It aims to provide novel therapies for these emotional disorders in pSS. |
| format | Article |
| id | doaj-art-fbb22c5fadb4448aa497852f3fe391f1 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-fbb22c5fadb4448aa497852f3fe391f12025-01-31T05:12:00ZengElsevierHeliyon2405-84402025-02-01113e42045Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insightYing Zhu0Kaiyuan Zhang1Ziyue Luo2Yu Song3Xinchang Wang4The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, ChinaThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China; College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, ChinaThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China; Corresponding author. The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China; Corresponding author. The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.Primary Sjogren's syndrome (pSS) is a prevalent disease in rheumatology and immunology. Anxiety, depression, and other mood disorders are pervasive across diverse sectors of society. Recent theories on the gut-brain axis have elucidated that the gut microbiota considered the second brain of humans, can modulate the central nervous system and behavior by mediating bidirectional response systems, including immunity, vagus nerve, and neuroendocrine pathways. This article reviews recent advancements that explore the mechanism between gut microbiota and emotional disorders in pSS. It aims to provide novel therapies for these emotional disorders in pSS.http://www.sciencedirect.com/science/article/pii/S2405844025004256Gut microbiotapSSAnxiety and depressionBrain-gut axisImmune dysfunction |
| spellingShingle | Ying Zhu Kaiyuan Zhang Ziyue Luo Yu Song Xinchang Wang Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight Heliyon Gut microbiota pSS Anxiety and depression Brain-gut axis Immune dysfunction |
| title | Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight |
| title_full | Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight |
| title_fullStr | Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight |
| title_full_unstemmed | Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight |
| title_short | Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight |
| title_sort | gut microbiota on anxiety and depression in primary sjogren s syndrome a novel insight |
| topic | Gut microbiota pSS Anxiety and depression Brain-gut axis Immune dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004256 |
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