Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients

Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients

Abstract Background Acute respiratory distress syndrome (ARDS) is causatively associated with excessive alveolar inflammation involving deregulated pro-inflammatory macrophage polarization. High-density lipoprotein (HDL) showed critical anti-inflammatory roles by modulating macrophage function, and...

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Bibliographic Details
Main Authors: Liu Yang, Zhuo Xu, Zhenyan Wang, Fangping Ding, Zhipeng Wu, Xiaoqian Shi, Jing Wang, Yingmin Ma, Jiawei Jin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
ARDS
Sepsis
Pro-SFTPB
HDL proteomics
Macrophage
Online Access:https://doi.org/10.1186/s12967-025-06100-6
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