Psychobiotics, Novel Therapeutic Agents for the Psychiatric Disorders
Various neurological disorders such as Parkinson’s disease, Alzheimer’s disease, autism spectrum disorder in young children, stress, anxiety etc., are afflicting the people all over the world. The pathophysiology of some of these disorders is not fully understood. Furthermore, the conventional the...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
The National Information and Documentation Centre (NIDOC) , Egypt
2025-02-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://researcherslinks.com/current-issues/Psychobiotics-Novel-Therapeutic-Agents/44/8/10553/html |
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| Summary: | Various neurological disorders such as Parkinson’s disease, Alzheimer’s disease, autism spectrum
disorder in young children, stress, anxiety etc., are afflicting the people all over the world. The pathophysiology
of some of these disorders is not fully understood. Furthermore, the conventional therapies are not effective
for all patients with psychiatric disorders. Hence, alternative therapeutic strategies/agents are much needed.
Clinical researchers suggest that certain microorganisms (beneficial microorganisms/probiotics) could be
substituted for conventional therapies and/ or can be used in combination with current drugs. Such beneficial
microorganisms which can influence the central nervous system and cure the neurological complications are
referred to as psychobiotics. In fact, the psychobiotics are the probiotic/ prebiotic agents which when present
in the human gut region will not only improve the gut health but also influence the central nervous system via
gut-brain axis, and counteract the symptoms of various neurological disorders. Till date, numerous probiotic
bacteria and prebiotic compounds were identified and the majority of them are able to influence the nervous
system. In various clinical trials on animal models and humans, it was proved that psychobiotics are effective
in ameliorating the clinical symptoms of neurological disorders. Some of the researchers are employing
psychobiotics in combination with traditional drugs for treatment of the psychiatric disorders. The aim of the
current review is to investigate the concept of psychobiotics, detailing their mechanisms of action and discussing
their potential applications in the treatment of certain psychiatric disorders. Subsequently, this study delineated
the characteristics of psychobiotics and highlighted their impacts on the nervous system. Additionally, various
psychobiotics utilized in the management of specific psychiatric conditions have been examined based on
numerous clinical trials and experiments conducted on both animal models and human subjects. |
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| ISSN: | 2537-0286 2537-0294 |