Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing
Summary: Sniffing is a specialized respiratory behavior that enables rodents to localize and track objects in their environment. The organum vasculosum of the lamina terminalis (OVLT) is critically involved in the regulation of thirst and water intake, yet its role in controlling thirst-driven explo...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000257 |
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| author | Wei He Luo Shi Ziteng Yue Ke Zhao Xiaoyi Wang Kailin Wang Xinyi Jing Shangyu Bi Tianjiao Deng Xue Zhao Xiaochen Tian Xiangchen Ma Yongqiang Chen Fang Yuan Sheng Wang |
| author_facet | Wei He Luo Shi Ziteng Yue Ke Zhao Xiaoyi Wang Kailin Wang Xinyi Jing Shangyu Bi Tianjiao Deng Xue Zhao Xiaochen Tian Xiangchen Ma Yongqiang Chen Fang Yuan Sheng Wang |
| author_sort | Wei He |
| collection | DOAJ |
| description | Summary: Sniffing is a specialized respiratory behavior that enables rodents to localize and track objects in their environment. The organum vasculosum of the lamina terminalis (OVLT) is critically involved in the regulation of thirst and water intake, yet its role in controlling thirst-driven exploratory sniffing behaviors remains unclear. This study demonstrates that hypertonic stimulation significantly increases sniffing and activates OVLT glutamatergic (OVLTGlut) neurons. Photostimulation of both OVLTGlut neurons and their axon terminals within the paraventricular nucleus of the hypothalamus (PVN) induces robust sniffing. Furthermore, ablation of PVN neurons projecting to the preBötzinger complex not only reduces the sniffing time induced by photostimulation of OVLTGlut neurons projecting to the PVN but also prolongs the drinking latency. These findings identify the OVLTGlut-PVN-preBötzinger complex circuit as a pivotal regulator of thirst-driven sniffing, providing insights into the neural mechanisms underlying thirst and exploratory behavior. |
| format | Article |
| id | doaj-art-fbb0c552ed7c4ffaa20802dd9e242e17 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-fbb0c552ed7c4ffaa20802dd9e242e172025-02-03T04:16:40ZengElsevierCell Reports2211-12472025-02-01442115254Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffingWei He0Luo Shi1Ziteng Yue2Ke Zhao3Xiaoyi Wang4Kailin Wang5Xinyi Jing6Shangyu Bi7Tianjiao Deng8Xue Zhao9Xiaochen Tian10Xiangchen Ma11Yongqiang Chen12Fang Yuan13Sheng Wang14Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Shijiazhuang, China; Corresponding authorDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Shijiazhuang, China; Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China; Corresponding authorSummary: Sniffing is a specialized respiratory behavior that enables rodents to localize and track objects in their environment. The organum vasculosum of the lamina terminalis (OVLT) is critically involved in the regulation of thirst and water intake, yet its role in controlling thirst-driven exploratory sniffing behaviors remains unclear. This study demonstrates that hypertonic stimulation significantly increases sniffing and activates OVLT glutamatergic (OVLTGlut) neurons. Photostimulation of both OVLTGlut neurons and their axon terminals within the paraventricular nucleus of the hypothalamus (PVN) induces robust sniffing. Furthermore, ablation of PVN neurons projecting to the preBötzinger complex not only reduces the sniffing time induced by photostimulation of OVLTGlut neurons projecting to the PVN but also prolongs the drinking latency. These findings identify the OVLTGlut-PVN-preBötzinger complex circuit as a pivotal regulator of thirst-driven sniffing, providing insights into the neural mechanisms underlying thirst and exploratory behavior.http://www.sciencedirect.com/science/article/pii/S2211124725000257CP: Neuroscience |
| spellingShingle | Wei He Luo Shi Ziteng Yue Ke Zhao Xiaoyi Wang Kailin Wang Xinyi Jing Shangyu Bi Tianjiao Deng Xue Zhao Xiaochen Tian Xiangchen Ma Yongqiang Chen Fang Yuan Sheng Wang Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing Cell Reports CP: Neuroscience |
| title | Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing |
| title_full | Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing |
| title_fullStr | Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing |
| title_full_unstemmed | Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing |
| title_short | Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing |
| title_sort | activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst driven sniffing |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000257 |
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