Dual Roles of IL-27 in Cancer Biology and Immunotherapy
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3958069 |
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| author | Marina Fabbi Grazia Carbotti Silvano Ferrini |
| author_facet | Marina Fabbi Grazia Carbotti Silvano Ferrini |
| author_sort | Marina Fabbi |
| collection | DOAJ |
| description | IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and STAT3. IL-27 was initially reported as an immune-enhancing cytokine that supports CD4+ T cell proliferation, T helper (Th)1 cell differentiation, and IFN-γ production, acting in concert with IL-12. However, subsequent studies demonstrated that IL-27 displays complex immune-regulatory functions, which may result in either proinflammatory or anti-inflammatory effects in relationship to the biological context and experimental models considered. Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential. Nonetheless, given its immune-regulatory functions, the effects of IL-27 on cancer may be dual and protumor effects may also occur. Here, we will summarize IL-27 biological activities and its functional overlaps with the IFNs and discuss its dual role in tumors in the light of potential applications to cancer immunotherapy. |
| format | Article |
| id | doaj-art-fbafe20697244b6bb54ebadee6fdeb1f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fbafe20697244b6bb54ebadee6fdeb1f2025-02-03T06:00:22ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/39580693958069Dual Roles of IL-27 in Cancer Biology and ImmunotherapyMarina Fabbi0Grazia Carbotti1Silvano Ferrini2Laboratory of Biotherapy, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, ItalyLaboratory of Biotherapy, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, ItalyLaboratory of Biotherapy, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, ItalyIL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and STAT3. IL-27 was initially reported as an immune-enhancing cytokine that supports CD4+ T cell proliferation, T helper (Th)1 cell differentiation, and IFN-γ production, acting in concert with IL-12. However, subsequent studies demonstrated that IL-27 displays complex immune-regulatory functions, which may result in either proinflammatory or anti-inflammatory effects in relationship to the biological context and experimental models considered. Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential. Nonetheless, given its immune-regulatory functions, the effects of IL-27 on cancer may be dual and protumor effects may also occur. Here, we will summarize IL-27 biological activities and its functional overlaps with the IFNs and discuss its dual role in tumors in the light of potential applications to cancer immunotherapy.http://dx.doi.org/10.1155/2017/3958069 |
| spellingShingle | Marina Fabbi Grazia Carbotti Silvano Ferrini Dual Roles of IL-27 in Cancer Biology and Immunotherapy Mediators of Inflammation |
| title | Dual Roles of IL-27 in Cancer Biology and Immunotherapy |
| title_full | Dual Roles of IL-27 in Cancer Biology and Immunotherapy |
| title_fullStr | Dual Roles of IL-27 in Cancer Biology and Immunotherapy |
| title_full_unstemmed | Dual Roles of IL-27 in Cancer Biology and Immunotherapy |
| title_short | Dual Roles of IL-27 in Cancer Biology and Immunotherapy |
| title_sort | dual roles of il 27 in cancer biology and immunotherapy |
| url | http://dx.doi.org/10.1155/2017/3958069 |
| work_keys_str_mv | AT marinafabbi dualrolesofil27incancerbiologyandimmunotherapy AT graziacarbotti dualrolesofil27incancerbiologyandimmunotherapy AT silvanoferrini dualrolesofil27incancerbiologyandimmunotherapy |