Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition
Cerebral palsy is a major neonatal handicap with unknown aetiology. There is evidence that prenatal brain injury is the leading cause of CP. Severe placental pathology accounts for a high percentage of cases. Several factors predispose to prenatal brain damage but when and how they act is unclear. T...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/809569 |
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| author | Begoña Pellicer Sonia Herraiz Antonio Leal Carlos Simón Antonio Pellicer |
| author_facet | Begoña Pellicer Sonia Herraiz Antonio Leal Carlos Simón Antonio Pellicer |
| author_sort | Begoña Pellicer |
| collection | DOAJ |
| description | Cerebral palsy is a major neonatal handicap with unknown aetiology. There is evidence that prenatal brain injury is the leading cause of CP. Severe placental pathology accounts for a high percentage of cases. Several factors predispose to prenatal brain damage but when and how they act is unclear. The aim of this paper was to determine if hypoxia during pregnancy leads to damage in fetal brain and to evaluate the localization of this injury. An animal model of chronic hypoxia produced by chronic administration of a nitric oxide synthase inhibitor (L-NAME) was used to evaluate apoptotic activity in fetal brains and to localize the most sensitive areas. L-NAME reproduces a preeclamptic-like condition with increased blood pressure, proteinuria, growth restriction and intrauterine mortality. Apoptotic activity was increased in L-NAME brains and the most sensitive areas were the subventricular and pallidum zone. These results may explain the clinical features of CP. Further studies are needed. |
| format | Article |
| id | doaj-art-fba76e94662248679f7c4010375e6e06 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-fba76e94662248679f7c4010375e6e062025-02-03T05:45:25ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/809569809569Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase InhibitionBegoña Pellicer0Sonia Herraiz1Antonio Leal2Carlos Simón3Antonio Pellicer4Servicio Ginecologia y Obstetricia, Hospital de Manises, C/Roses s/n, 46940 Valencia, SpainValencian Node of the National Stem Cell Bank, Prince Felipe Research Centre, 46012 Valencia, SpainServicio Ginecologia y Obstetricia, Hospital de Manises, C/Roses s/n, 46940 Valencia, SpainValencian Node of the National Stem Cell Bank, Prince Felipe Research Centre, 46012 Valencia, SpainFundación IVI-Instituto Universitario IVI, Universitat de València, 46015 València, SpainCerebral palsy is a major neonatal handicap with unknown aetiology. There is evidence that prenatal brain injury is the leading cause of CP. Severe placental pathology accounts for a high percentage of cases. Several factors predispose to prenatal brain damage but when and how they act is unclear. The aim of this paper was to determine if hypoxia during pregnancy leads to damage in fetal brain and to evaluate the localization of this injury. An animal model of chronic hypoxia produced by chronic administration of a nitric oxide synthase inhibitor (L-NAME) was used to evaluate apoptotic activity in fetal brains and to localize the most sensitive areas. L-NAME reproduces a preeclamptic-like condition with increased blood pressure, proteinuria, growth restriction and intrauterine mortality. Apoptotic activity was increased in L-NAME brains and the most sensitive areas were the subventricular and pallidum zone. These results may explain the clinical features of CP. Further studies are needed.http://dx.doi.org/10.1155/2011/809569 |
| spellingShingle | Begoña Pellicer Sonia Herraiz Antonio Leal Carlos Simón Antonio Pellicer Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition Journal of Pregnancy |
| title | Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition |
| title_full | Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition |
| title_fullStr | Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition |
| title_full_unstemmed | Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition |
| title_short | Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition |
| title_sort | prenatal brain damage in preeclamptic animal model induced by gestational nitric oxide synthase inhibition |
| url | http://dx.doi.org/10.1155/2011/809569 |
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