Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms

ROCK inhibitors such as fasudil protected against dopaminergic degeneration and other neurodegenerative processes in several experimental models through inhibition of neuroinflammation and activation of survival signaling pathways, and clinical trials have been initiated. More recently, fasudil has...

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Bibliographic Details
Main Authors: Lucia Lage, Ana I. Rodriguez-Perez, Jose Luis Labandeira-Garcia, Antonio Dominguez-Meijide
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
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Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925000224
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