Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018
Abstract This cross-sectional study aimed to investigate the association between the TyG index and both obesity indicators and hypertension among American adults. Data were drawn from 4,813 adults in the 2013–2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regre...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-86430-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585819156643840 |
|---|---|
| author | Pingping Huang Hongwei Zhang Gaocan Ren Yifei Wang Shuangqing Fu Yicheng Liu Zhibo Zhang Lijun Guo Xiaochang Ma |
| author_facet | Pingping Huang Hongwei Zhang Gaocan Ren Yifei Wang Shuangqing Fu Yicheng Liu Zhibo Zhang Lijun Guo Xiaochang Ma |
| author_sort | Pingping Huang |
| collection | DOAJ |
| description | Abstract This cross-sectional study aimed to investigate the association between the TyG index and both obesity indicators and hypertension among American adults. Data were drawn from 4,813 adults in the 2013–2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression models indicated significant associations between TyG and obesity-related indices with hypertension. Using Cox regression analysis, we examined the relationship between TyG and obesity-related indices in relation to hypertensive prognosis, employing threshold effect analysis and fitted smoothed curves for consistency. Subgroup analyses and interaction tests were conducted. Results showed strong correlations between TyG, TyG-BMI, TyG-WHtR, TyG-WC and hypertension, with odds ratios (ORs) of hypertension rising across TyG quartiles (Q1–Q4). Cardiovascular mortality analysis revealed that TyG (HR = 1.89, 95% CI (1.03,3.51), P < 0.05) and the Q2 group (HR = 4.93, 95% CI (1.29,18.80), P < 0.05) were significantly associated with increased risk. A positive correlation between TyG and hypertension was noted below a threshold of 8.1, with inverse associations beyond this point. The TyG-BMI, TyG-WHtR, and TyG-WC exhibited positive correlations with hypertension, although weakened after reaching a certain threshold. These findings suggested that TyG and related indices are associated with hypertension and may aid in understanding risk stratification in this context. |
| format | Article |
| id | doaj-art-fb8e4bb907e8487387cb7d8c2a8503c7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-fb8e4bb907e8487387cb7d8c2a8503c72025-01-26T12:32:18ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-86430-zAssociation of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018Pingping Huang0Hongwei Zhang1Gaocan Ren2Yifei Wang3Shuangqing Fu4Yicheng Liu5Zhibo Zhang6Lijun Guo7Xiaochang Ma8Xiyuan Hospital, China Academy of Chinese Medical SciencesXiyuan Hospital, China Academy of Chinese Medical SciencesXiyuan Hospital, China Academy of Chinese Medical SciencesGraduate School, China Academy of Chinese Medical SciencesGraduate School, China Academy of Chinese Medical SciencesXiyuan Hospital, China Academy of Chinese Medical SciencesGraduate School, China Academy of Chinese Medical SciencesNational Clinical Research Center for Chinese Medicine CardiologyNational Clinical Research Center for Chinese Medicine CardiologyAbstract This cross-sectional study aimed to investigate the association between the TyG index and both obesity indicators and hypertension among American adults. Data were drawn from 4,813 adults in the 2013–2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression models indicated significant associations between TyG and obesity-related indices with hypertension. Using Cox regression analysis, we examined the relationship between TyG and obesity-related indices in relation to hypertensive prognosis, employing threshold effect analysis and fitted smoothed curves for consistency. Subgroup analyses and interaction tests were conducted. Results showed strong correlations between TyG, TyG-BMI, TyG-WHtR, TyG-WC and hypertension, with odds ratios (ORs) of hypertension rising across TyG quartiles (Q1–Q4). Cardiovascular mortality analysis revealed that TyG (HR = 1.89, 95% CI (1.03,3.51), P < 0.05) and the Q2 group (HR = 4.93, 95% CI (1.29,18.80), P < 0.05) were significantly associated with increased risk. A positive correlation between TyG and hypertension was noted below a threshold of 8.1, with inverse associations beyond this point. The TyG-BMI, TyG-WHtR, and TyG-WC exhibited positive correlations with hypertension, although weakened after reaching a certain threshold. These findings suggested that TyG and related indices are associated with hypertension and may aid in understanding risk stratification in this context.https://doi.org/10.1038/s41598-025-86430-zTyGHypertensionNHANESCross-sectional studyTyG-BMITyG-WHtR |
| spellingShingle | Pingping Huang Hongwei Zhang Gaocan Ren Yifei Wang Shuangqing Fu Yicheng Liu Zhibo Zhang Lijun Guo Xiaochang Ma Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 Scientific Reports TyG Hypertension NHANES Cross-sectional study TyG-BMI TyG-WHtR |
| title | Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 |
| title_full | Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 |
| title_fullStr | Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 |
| title_full_unstemmed | Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 |
| title_short | Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 |
| title_sort | association of the triglyceride glucose index with obesity indicators and hypertension in american adults based on nhanes 2013 to 2018 |
| topic | TyG Hypertension NHANES Cross-sectional study TyG-BMI TyG-WHtR |
| url | https://doi.org/10.1038/s41598-025-86430-z |
| work_keys_str_mv | AT pingpinghuang associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT hongweizhang associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT gaocanren associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT yifeiwang associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT shuangqingfu associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT yichengliu associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT zhibozhang associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT lijunguo associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 AT xiaochangma associationofthetriglycerideglucoseindexwithobesityindicatorsandhypertensioninamericanadultsbasedonnhanes2013to2018 |