Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis
Plasma cell neoplasms may have variable morphologic and immunophenotypic features. This patient case demonstrates a rare presentation of plasma cell myeloma with negative CD138 expression and lymphoplasmacytic morphology. In this report, we discuss the possible differential diagnosis and highlight t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-11-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0691 |
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| _version_ | 1850202431185485824 |
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| author | Razan Baloush Vishnu Reddy |
| author_facet | Razan Baloush Vishnu Reddy |
| author_sort | Razan Baloush |
| collection | DOAJ |
| description | Plasma cell neoplasms may have variable morphologic and immunophenotypic features. This patient case demonstrates a rare presentation of plasma cell myeloma with negative CD138 expression and lymphoplasmacytic morphology. In this report, we discuss the possible differential diagnosis and highlight the importance of a comprehensive diagnostic approach including flow cytometry, immunohistochemistry, and molecular studies to arrive at the correct diagnosis. |
| format | Article |
| id | doaj-art-fb8b474960a149f9ac0f3d4b6fb2e4d3 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-fb8b474960a149f9ac0f3d4b6fb2e4d32025-08-20T02:11:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-11-011910.7326/aimcc.2022.0691Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential DiagnosisRazan Baloush0Vishnu Reddy11University of Alabama at Birmingham, Birmingham, Alabama1University of Alabama at Birmingham, Birmingham, AlabamaPlasma cell neoplasms may have variable morphologic and immunophenotypic features. This patient case demonstrates a rare presentation of plasma cell myeloma with negative CD138 expression and lymphoplasmacytic morphology. In this report, we discuss the possible differential diagnosis and highlight the importance of a comprehensive diagnostic approach including flow cytometry, immunohistochemistry, and molecular studies to arrive at the correct diagnosis.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0691 |
| spellingShingle | Razan Baloush Vishnu Reddy Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis Annals of Internal Medicine: Clinical Cases |
| title | Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis |
| title_full | Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis |
| title_fullStr | Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis |
| title_full_unstemmed | Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis |
| title_short | Plasma Cell Myeloma With Lymphoplasmacytic Morphology and Negative CD138 Expression: Case Report and Differential Diagnosis |
| title_sort | plasma cell myeloma with lymphoplasmacytic morphology and negative cd138 expression case report and differential diagnosis |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0691 |
| work_keys_str_mv | AT razanbaloush plasmacellmyelomawithlymphoplasmacyticmorphologyandnegativecd138expressioncasereportanddifferentialdiagnosis AT vishnureddy plasmacellmyelomawithlymphoplasmacyticmorphologyandnegativecd138expressioncasereportanddifferentialdiagnosis |