Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential
Unsweetened natural cocoa (UNCP) was evaluated for reproductive toxicity in rats. A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. White Wistar rats were used in two...
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2021-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2021/6114672 |
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| author | I. J. Asiedu-Gyekye T. G. Borovskaya M. E. Poluektova А. V. Vychuzhanina Y. А. Shchemerovа S. I. Kamalova V. A. Grgoreva P. Amoateng K. E. Kukuia A. A. Kwapong L. Allotey Babington S. K. Amponsah B. B. N’guessan |
| author_facet | I. J. Asiedu-Gyekye T. G. Borovskaya M. E. Poluektova А. V. Vychuzhanina Y. А. Shchemerovа S. I. Kamalova V. A. Grgoreva P. Amoateng K. E. Kukuia A. A. Kwapong L. Allotey Babington S. K. Amponsah B. B. N’guessan |
| author_sort | I. J. Asiedu-Gyekye |
| collection | DOAJ |
| description | Unsweetened natural cocoa (UNCP) was evaluated for reproductive toxicity in rats. A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. White Wistar rats were used in two experimental groups. The females received UNCP 15 days before crossing with untreated males. The males received UNCP for 48 days before mating with untreated females. Subacute toxicity was observed during a 14-day oral administration of UNCP. Results show that a high tail DNA% was observed with methyl mesylate administration in all tissues analysed. The lowest tail DNA% value was observed in the liver (1.64 ± 0.26) and kidney (1.63 ± 0.30) during UNCP (TD) administration. UNCP did not induce observable physical congenital malformations on the pubs of treated female and male rats, lacks genotoxic potential, and did not adversely affect pregnancy index, pub weights, and survival index, but UNCP exhibited proimplantation potential (p>0.05). |
| format | Article |
| id | doaj-art-fb83f7644a9046ca8fdbe07eb690135a |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-fb83f7644a9046ca8fdbe07eb690135a2025-02-03T06:01:48ZengWileyJournal of Toxicology1687-81911687-82052021-01-01202110.1155/2021/61146726114672Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation PotentialI. J. Asiedu-Gyekye0T. G. Borovskaya1M. E. Poluektova2А. V. Vychuzhanina3Y. А. Shchemerovа4S. I. Kamalova5V. A. Grgoreva6P. Amoateng7K. E. Kukuia8A. A. Kwapong9L. Allotey Babington10S. K. Amponsah11B. B. N’guessan12Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaDepartment of Pharmaceutics and Microbiology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaDepartment of Pharmaceutics and Microbiology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, GhanaUnsweetened natural cocoa (UNCP) was evaluated for reproductive toxicity in rats. A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. White Wistar rats were used in two experimental groups. The females received UNCP 15 days before crossing with untreated males. The males received UNCP for 48 days before mating with untreated females. Subacute toxicity was observed during a 14-day oral administration of UNCP. Results show that a high tail DNA% was observed with methyl mesylate administration in all tissues analysed. The lowest tail DNA% value was observed in the liver (1.64 ± 0.26) and kidney (1.63 ± 0.30) during UNCP (TD) administration. UNCP did not induce observable physical congenital malformations on the pubs of treated female and male rats, lacks genotoxic potential, and did not adversely affect pregnancy index, pub weights, and survival index, but UNCP exhibited proimplantation potential (p>0.05).http://dx.doi.org/10.1155/2021/6114672 |
| spellingShingle | I. J. Asiedu-Gyekye T. G. Borovskaya M. E. Poluektova А. V. Vychuzhanina Y. А. Shchemerovа S. I. Kamalova V. A. Grgoreva P. Amoateng K. E. Kukuia A. A. Kwapong L. Allotey Babington S. K. Amponsah B. B. N’guessan Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential Journal of Toxicology |
| title | Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential |
| title_full | Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential |
| title_fullStr | Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential |
| title_full_unstemmed | Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential |
| title_short | Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential |
| title_sort | reproductive toxicity of theobroma cacao increase in survival index nongenotoxic and proimplantation potential |
| url | http://dx.doi.org/10.1155/2021/6114672 |
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