The Effects of Affinity Mediated Clonal Expansion of Premigrant Thymocytes on the Periphery T-Cell Repertoire
The immune system maintains a highly diverse T-cell repertoire,which is shaped by active interactions between developing thymocytesand endogenous peptide/MHC molecules through the principle ofpositive and negative selections. Detours et al. developed aquantitative model addressing key immunologic no...
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Format: | Article |
Language: | English |
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AIMS Press
2004-10-01
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Series: | Mathematical Biosciences and Engineering |
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Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.153 |
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