Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis
We conducted a retrospective analysis of 68 newly diagnosed myelodysplastic syndrome (MDS) patients who were treated in the Department of Hematology at Yuncheng Central Hospital affiliated to Shanxi Medical University from October 2017 to March 2022. Based on the serum ferritin (SF) level, the newly...
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Taylor & Francis Group
2024-12-01
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| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2406558 |
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| author | Lixiang Duan Wenjun Yu Xiaolin Jiao Ying Sun Yao Fang Ma Le Li Zeqiang Nie Dan Zhao |
| author_facet | Lixiang Duan Wenjun Yu Xiaolin Jiao Ying Sun Yao Fang Ma Le Li Zeqiang Nie Dan Zhao |
| author_sort | Lixiang Duan |
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| description | We conducted a retrospective analysis of 68 newly diagnosed myelodysplastic syndrome (MDS) patients who were treated in the Department of Hematology at Yuncheng Central Hospital affiliated to Shanxi Medical University from October 2017 to March 2022. Based on the serum ferritin (SF) level, the newly diagnosed MDS patients were divided into two groups: iron overload (IOL) group (SF > 1000 ng/mL) and non-iron overload (NIOL) group(SF ≤ 1000 ng/mL). General clinical data, peripheral blood cells, lymphocyte subsets and marrow karyotypes were compared. We found that MDS patients with IOL had lower hemoglobin (Hb), lower reticulocyte (RET) counts, and lower absolute natural killer (NK) cell counts compared with NIOL group (p < 0.05). The correlation analysis also showed a negative correlation between the NK cell counts and SF level (r = −0.270, P = 0.026). Furthermore, we found IOL group had higher incidence of complex and poor karyotypes. In conclusion, we found that IOL is correlated with anemia in MDS patients, which may lead to a decrease in T lymphocyte cells, especially in NK cells, that play a role in the immune pathogenesis of MDS, thereby suppressing immune surveillance function. Additionally, IOL may contribute to the pathogenesis of MDS by affecting karyotypes. |
| format | Article |
| id | doaj-art-fb70825aff6b436ba135b7327a1e3c30 |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-fb70825aff6b436ba135b7327a1e3c302025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.24065582406558Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysisLixiang Duan0Wenjun Yu1Xiaolin Jiao2Ying Sun3Yao Fang Ma4Le Li5Zeqiang Nie6Dan Zhao7Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)Yuncheng Central Hospital of Shanxi Province (Yuncheng Central Hospital Affiliated to Shanxi Medical University)We conducted a retrospective analysis of 68 newly diagnosed myelodysplastic syndrome (MDS) patients who were treated in the Department of Hematology at Yuncheng Central Hospital affiliated to Shanxi Medical University from October 2017 to March 2022. Based on the serum ferritin (SF) level, the newly diagnosed MDS patients were divided into two groups: iron overload (IOL) group (SF > 1000 ng/mL) and non-iron overload (NIOL) group(SF ≤ 1000 ng/mL). General clinical data, peripheral blood cells, lymphocyte subsets and marrow karyotypes were compared. We found that MDS patients with IOL had lower hemoglobin (Hb), lower reticulocyte (RET) counts, and lower absolute natural killer (NK) cell counts compared with NIOL group (p < 0.05). The correlation analysis also showed a negative correlation between the NK cell counts and SF level (r = −0.270, P = 0.026). Furthermore, we found IOL group had higher incidence of complex and poor karyotypes. In conclusion, we found that IOL is correlated with anemia in MDS patients, which may lead to a decrease in T lymphocyte cells, especially in NK cells, that play a role in the immune pathogenesis of MDS, thereby suppressing immune surveillance function. Additionally, IOL may contribute to the pathogenesis of MDS by affecting karyotypes.http://dx.doi.org/10.1080/26895293.2024.2406558iron overloadmyelodysplastic syndromelymphocyte subsetsperipheral blood cellskaryotype |
| spellingShingle | Lixiang Duan Wenjun Yu Xiaolin Jiao Ying Sun Yao Fang Ma Le Li Zeqiang Nie Dan Zhao Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis All Life iron overload myelodysplastic syndrome lymphocyte subsets peripheral blood cells karyotype |
| title | Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis |
| title_full | Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis |
| title_fullStr | Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis |
| title_full_unstemmed | Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis |
| title_short | Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis |
| title_sort | iron overload impact on peripheral blood cells lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes mds patients a single center retrospective analysis |
| topic | iron overload myelodysplastic syndrome lymphocyte subsets peripheral blood cells karyotype |
| url | http://dx.doi.org/10.1080/26895293.2024.2406558 |
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