Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding
Multiple myeloma (MM) is associated with the secretion of a unique monoclonal protein (M-protein) due to overproduction of immunoglobulin (Ig) by a clone of abnormally proliferating plasma cells. However, in 4% of the cases more than one M-protein can be found. This category of gammopathies is calle...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_904_21 |
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| author | Rajni Saijpaul Vatsala Khurana Rashmi Verma Smita Kaushik |
| author_facet | Rajni Saijpaul Vatsala Khurana Rashmi Verma Smita Kaushik |
| author_sort | Rajni Saijpaul |
| collection | DOAJ |
| description | Multiple myeloma (MM) is associated with the secretion of a unique monoclonal protein (M-protein) due to overproduction of immunoglobulin (Ig) by a clone of abnormally proliferating plasma cells. However, in 4% of the cases more than one M-protein can be found. This category of gammopathies is called “double monoclonal gammopathies.” Here, we present a rare case of MM with double monoclonal gammopathy, where the presence of both M-proteins was observed in the single sharp peak on capillary zone electrophoresis (CZE). Further the interference of Hook effect is also discussed. Double monoclonal gammopathies need to be identified to increase diagnostic accuracy and reliability, and to get a better understanding of the disease pathogenesis and progression. |
| format | Article |
| id | doaj-art-fb62aec827d74b6690e1da75690ef4b7 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-fb62aec827d74b6690e1da75690ef4b72025-01-22T15:14:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-01-0167119219410.4103/ijpm.ijpm_904_21Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare findingRajni SaijpaulVatsala KhuranaRashmi VermaSmita KaushikMultiple myeloma (MM) is associated with the secretion of a unique monoclonal protein (M-protein) due to overproduction of immunoglobulin (Ig) by a clone of abnormally proliferating plasma cells. However, in 4% of the cases more than one M-protein can be found. This category of gammopathies is called “double monoclonal gammopathies.” Here, we present a rare case of MM with double monoclonal gammopathy, where the presence of both M-proteins was observed in the single sharp peak on capillary zone electrophoresis (CZE). Further the interference of Hook effect is also discussed. Double monoclonal gammopathies need to be identified to increase diagnostic accuracy and reliability, and to get a better understanding of the disease pathogenesis and progression.https://journals.lww.com/10.4103/ijpm.ijpm_904_21capillary electrophoresisdouble monoclonal gammopathyhook effectmultiple myeloma |
| spellingShingle | Rajni Saijpaul Vatsala Khurana Rashmi Verma Smita Kaushik Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding Indian Journal of Pathology and Microbiology capillary electrophoresis double monoclonal gammopathy hook effect multiple myeloma |
| title | Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding |
| title_full | Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding |
| title_fullStr | Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding |
| title_full_unstemmed | Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding |
| title_short | Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding |
| title_sort | single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma a rare finding |
| topic | capillary electrophoresis double monoclonal gammopathy hook effect multiple myeloma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_904_21 |
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