A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study
Prebiotic dietary fiber (PDF) may reduce feelings of stress or improve mood in healthy individuals. Yet gut intervention studies that focus on mood in daily life are lacking and few studies include extensive biological sample analyses to gain mechanistic insights. As part of a larger randomized plac...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354624001960 |
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| author | Koen Hogenelst Tanja Krone Boukje Eveleens Maarse Ines Warnke Jessica Snabel Tim J. van den Broek Frank Schuren Matthijs Moerland Femke P.M. Hoevenaars |
| author_facet | Koen Hogenelst Tanja Krone Boukje Eveleens Maarse Ines Warnke Jessica Snabel Tim J. van den Broek Frank Schuren Matthijs Moerland Femke P.M. Hoevenaars |
| author_sort | Koen Hogenelst |
| collection | DOAJ |
| description | Prebiotic dietary fiber (PDF) may reduce feelings of stress or improve mood in healthy individuals. Yet gut intervention studies that focus on mood in daily life are lacking and few studies include extensive biological sample analyses to gain mechanistic insights. As part of a larger randomized placebo-controlled crossover study including healthy individuals, we explored the effects of 12 weeks of PDF (acacia gum and carrot powder) on everyday mood, as measured with ecological momentary assessment (EMA). Microbiome composition and levels of microbial metabolites, endocrine, and inflammatory markers were determined prior to and after both intervention phases. Fifty-four participants completed the study. The intervention significantly increased daily positive affect (PA) and reduced daily negative affect (NA) in female but not male participants. The intervention-induced reduction in NA was associated with an increase in microbial diversity in female participants. The intervention did not significantly affect levels of fecal short chain fatty acids, cortisol, and inflammatory markers. This is one of the first studies to show that a dietary fiber intervention can positively alter mood as it is experienced in everyday life. Overall, our findings may stimulate more targeted gut-microbiome interventions and detection of its mental health effects in real life. |
| format | Article |
| id | doaj-art-fb60c3b64c7f4a678ab16543901d3b09 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-fb60c3b64c7f4a678ab16543901d3b092025-01-26T05:04:59ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-02-0143100918A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over studyKoen Hogenelst0Tanja Krone1Boukje Eveleens Maarse2Ines Warnke3Jessica Snabel4Tim J. van den Broek5Frank Schuren6Matthijs Moerland7Femke P.M. Hoevenaars8Department of Human Performance, The Netherlands Organisation for Applied Scientific Research (TNO), Soesterberg, the NetherlandsDepartment of Risk Analysis for Products in Development, The Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, the NetherlandsCentre for Human Drug Research, Leiden, the Netherlands; Leiden University Medical Center, Leiden, the NetherlandsDSM -Firmenich, Kaiseraugst, SwitzerlandDepartment of Metabolic Health Research, The Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the NetherlandsDepartment of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the NetherlandsDepartment of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the NetherlandsCentre for Human Drug Research, Leiden, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands; Corresponding author. Centre for Human Drug Research, Leiden, the NetherlandsDepartment of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the NetherlandsPrebiotic dietary fiber (PDF) may reduce feelings of stress or improve mood in healthy individuals. Yet gut intervention studies that focus on mood in daily life are lacking and few studies include extensive biological sample analyses to gain mechanistic insights. As part of a larger randomized placebo-controlled crossover study including healthy individuals, we explored the effects of 12 weeks of PDF (acacia gum and carrot powder) on everyday mood, as measured with ecological momentary assessment (EMA). Microbiome composition and levels of microbial metabolites, endocrine, and inflammatory markers were determined prior to and after both intervention phases. Fifty-four participants completed the study. The intervention significantly increased daily positive affect (PA) and reduced daily negative affect (NA) in female but not male participants. The intervention-induced reduction in NA was associated with an increase in microbial diversity in female participants. The intervention did not significantly affect levels of fecal short chain fatty acids, cortisol, and inflammatory markers. This is one of the first studies to show that a dietary fiber intervention can positively alter mood as it is experienced in everyday life. Overall, our findings may stimulate more targeted gut-microbiome interventions and detection of its mental health effects in real life.http://www.sciencedirect.com/science/article/pii/S2666354624001960PrebioticsMicrobiomePositive affectNegative affectEcological momentary assessmentCortisol |
| spellingShingle | Koen Hogenelst Tanja Krone Boukje Eveleens Maarse Ines Warnke Jessica Snabel Tim J. van den Broek Frank Schuren Matthijs Moerland Femke P.M. Hoevenaars A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study Brain, Behavior, & Immunity - Health Prebiotics Microbiome Positive affect Negative affect Ecological momentary assessment Cortisol |
| title | A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study |
| title_full | A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study |
| title_fullStr | A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study |
| title_full_unstemmed | A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study |
| title_short | A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study |
| title_sort | prebiotic intervention improves mood in everyday life in healthy women but not in men exploratory results from a larger double blind placebo controlled cross over study |
| topic | Prebiotics Microbiome Positive affect Negative affect Ecological momentary assessment Cortisol |
| url | http://www.sciencedirect.com/science/article/pii/S2666354624001960 |
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