Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy
Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected d...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/9204574 |
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| author | Ting Gong Boon Chin Heng Edward Chin Man Lo Chengfei Zhang |
| author_facet | Ting Gong Boon Chin Heng Edward Chin Man Lo Chengfei Zhang |
| author_sort | Ting Gong |
| collection | DOAJ |
| description | Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration. |
| format | Article |
| id | doaj-art-fb5ea570b5f2494da8f0c33859877536 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-fb5ea570b5f2494da8f0c338598775362025-02-03T06:01:39ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/92045749204574Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative TherapyTing Gong0Boon Chin Heng1Edward Chin Man Lo2Chengfei Zhang3Comprehensive Dental Care, Endodontics, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong KongComprehensive Dental Care, Endodontics, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong KongPeriodontology and Public Health, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong KongComprehensive Dental Care, Endodontics, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong KongRecent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration.http://dx.doi.org/10.1155/2016/9204574 |
| spellingShingle | Ting Gong Boon Chin Heng Edward Chin Man Lo Chengfei Zhang Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy Stem Cells International |
| title | Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy |
| title_full | Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy |
| title_fullStr | Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy |
| title_full_unstemmed | Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy |
| title_short | Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy |
| title_sort | current advance and future prospects of tissue engineering approach to dentin pulp regenerative therapy |
| url | http://dx.doi.org/10.1155/2016/9204574 |
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