Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma
Salivary ductal carcinomas (SDCs) are extremely rare and aggressive malignancies, accounting for approximately 6% of all salivary gland malignancies. One distinct feature is their resemblance to ductal carcinomas of breast. A significant percentage of SDCs overexpress Her2 and the use of targeted th...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/162534 |
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| _version_ | 1832552335853748224 |
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| author | Muhammad Shahid Iqbal Ghazia Shaikh Sanjoy Chatterjee Helen Cocks Josef Kovarik |
| author_facet | Muhammad Shahid Iqbal Ghazia Shaikh Sanjoy Chatterjee Helen Cocks Josef Kovarik |
| author_sort | Muhammad Shahid Iqbal |
| collection | DOAJ |
| description | Salivary ductal carcinomas (SDCs) are extremely rare and aggressive malignancies, accounting for approximately 6% of all salivary gland malignancies. One distinct feature is their resemblance to ductal carcinomas of breast. A significant percentage of SDCs overexpress Her2 and the use of targeted therapy with trastuzumab can be considered in these patients. We report a rare case of long term disease control with trastuzumab in Her2 positive metastatic parotid ductal carcinoma. Our case also highlights that isolated brain metastasis should be managed aggressively to allow optimal local control when systemic disease is under remission with trastuzumab. We have also reviewed the published literature on the use of trastuzumab in SDCs. |
| format | Article |
| id | doaj-art-fb50b15d9fc34e42ad7df31909000474 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-fb50b15d9fc34e42ad7df319090004742025-02-03T05:58:57ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/162534162534Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal AdenocarcinomaMuhammad Shahid Iqbal0Ghazia Shaikh1Sanjoy Chatterjee2Helen Cocks3Josef Kovarik4Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UKDepartment of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UKDepartment of Oncology, Tata Medical Centre, Kolkata 700 156, IndiaDepartment of Otolaryngology, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UKDepartment of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UKSalivary ductal carcinomas (SDCs) are extremely rare and aggressive malignancies, accounting for approximately 6% of all salivary gland malignancies. One distinct feature is their resemblance to ductal carcinomas of breast. A significant percentage of SDCs overexpress Her2 and the use of targeted therapy with trastuzumab can be considered in these patients. We report a rare case of long term disease control with trastuzumab in Her2 positive metastatic parotid ductal carcinoma. Our case also highlights that isolated brain metastasis should be managed aggressively to allow optimal local control when systemic disease is under remission with trastuzumab. We have also reviewed the published literature on the use of trastuzumab in SDCs.http://dx.doi.org/10.1155/2014/162534 |
| spellingShingle | Muhammad Shahid Iqbal Ghazia Shaikh Sanjoy Chatterjee Helen Cocks Josef Kovarik Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma Case Reports in Oncological Medicine |
| title | Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma |
| title_full | Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma |
| title_fullStr | Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma |
| title_full_unstemmed | Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma |
| title_short | Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma |
| title_sort | maintenance therapy with trastuzumab in her2 positive metastatic parotid ductal adenocarcinoma |
| url | http://dx.doi.org/10.1155/2014/162534 |
| work_keys_str_mv | AT muhammadshahidiqbal maintenancetherapywithtrastuzumabinher2positivemetastaticparotidductaladenocarcinoma AT ghaziashaikh maintenancetherapywithtrastuzumabinher2positivemetastaticparotidductaladenocarcinoma AT sanjoychatterjee maintenancetherapywithtrastuzumabinher2positivemetastaticparotidductaladenocarcinoma AT helencocks maintenancetherapywithtrastuzumabinher2positivemetastaticparotidductaladenocarcinoma AT josefkovarik maintenancetherapywithtrastuzumabinher2positivemetastaticparotidductaladenocarcinoma |