Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control
The influence of cardiorespiratory fitness (VO2max) on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups. VO2max was determined by progressive maximal exercise te...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/538732 |
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| author | Marcos Roberto Queiroga Ricardo Augusto Barbieri Sandra Aires Ferreira André Ducati Luchessi Rosario Dominguez Crespo Hirata Mario Hiroyuki Hirata Eduardo Kokubun |
| author_facet | Marcos Roberto Queiroga Ricardo Augusto Barbieri Sandra Aires Ferreira André Ducati Luchessi Rosario Dominguez Crespo Hirata Mario Hiroyuki Hirata Eduardo Kokubun |
| author_sort | Marcos Roberto Queiroga |
| collection | DOAJ |
| description | The influence of cardiorespiratory fitness (VO2max) on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups. VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis. Body mass (BM), BMI, waist circumference (WC), triceps (TR), and subscapular (SB) skinfold thicknesses were measured. Twins from the discordant group had differences in VO2max values (D-high = 45.9±10.0 versus D-low = 32.4±10.6 mL·kg−1·min−1, P=0.025), while no differences were found in the concordant group (C-high = 42.4±9.2 versus C-low = 38.8±9.8 mL·kg−1·min−1, P=0.952). In discordant group, VO2max was negatively correlated with TR + SB (r=-0.540, P=0.021) and positively correlated with PPARG expression in leukocytes (r=0.952, P=0.001). Moreover, PPARG expression was directly correlated with BM (r=0.714, P=0.047) and height (r=0.762, P=0.028). In concordant twins, VO2max was inversely correlated with BM (r=-0.290, P=0.027), BMI (r=-0.472, P=0.001), WC (r=-0.426, P=0.001), and TR + SB (r=-0.739, P=0.001). Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low (P=0.048). In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background. |
| format | Article |
| id | doaj-art-fb4b67218bc14b42b9e41fea14facb97 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fb4b67218bc14b42b9e41fea14facb972025-02-03T01:20:54ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/538732538732Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case ControlMarcos Roberto Queiroga0Ricardo Augusto Barbieri1Sandra Aires Ferreira2André Ducati Luchessi3Rosario Dominguez Crespo Hirata4Mario Hiroyuki Hirata5Eduardo Kokubun6Departamento de Educação Física da Universidade Estadual do Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sá, 03, 85040-080 Guarapuava, PR, BrazilDepartamento de Educação Física da Universidade Estadual Paulista (UNESP), Avenida 24 A 1515, 13506-900 Rio Claro, SP, BrazilDepartamento de Educação Física da Universidade Estadual do Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sá, 03, 85040-080 Guarapuava, PR, BrazilDepartamento de Análises Clínicas e Toxicológicas da Universidade Federal do Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, 384, 59012-570 Natal, RN, BrazilDepartamento de Análises Clínicas e Toxicológicas da Universidade de São Paulo (USP), Avenida Professor Lineu Prestes, 580, 05508-000 São Paulo, SP, BrazilDepartamento de Análises Clínicas e Toxicológicas da Universidade de São Paulo (USP), Avenida Professor Lineu Prestes, 580, 05508-000 São Paulo, SP, BrazilDepartamento de Educação Física da Universidade Estadual Paulista (UNESP), Avenida 24 A 1515, 13506-900 Rio Claro, SP, BrazilThe influence of cardiorespiratory fitness (VO2max) on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups. VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis. Body mass (BM), BMI, waist circumference (WC), triceps (TR), and subscapular (SB) skinfold thicknesses were measured. Twins from the discordant group had differences in VO2max values (D-high = 45.9±10.0 versus D-low = 32.4±10.6 mL·kg−1·min−1, P=0.025), while no differences were found in the concordant group (C-high = 42.4±9.2 versus C-low = 38.8±9.8 mL·kg−1·min−1, P=0.952). In discordant group, VO2max was negatively correlated with TR + SB (r=-0.540, P=0.021) and positively correlated with PPARG expression in leukocytes (r=0.952, P=0.001). Moreover, PPARG expression was directly correlated with BM (r=0.714, P=0.047) and height (r=0.762, P=0.028). In concordant twins, VO2max was inversely correlated with BM (r=-0.290, P=0.027), BMI (r=-0.472, P=0.001), WC (r=-0.426, P=0.001), and TR + SB (r=-0.739, P=0.001). Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low (P=0.048). In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.http://dx.doi.org/10.1155/2015/538732 |
| spellingShingle | Marcos Roberto Queiroga Ricardo Augusto Barbieri Sandra Aires Ferreira André Ducati Luchessi Rosario Dominguez Crespo Hirata Mario Hiroyuki Hirata Eduardo Kokubun Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control Journal of Diabetes Research |
| title | Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control |
| title_full | Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control |
| title_fullStr | Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control |
| title_full_unstemmed | Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control |
| title_short | Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control |
| title_sort | influence of cardiorespiratory fitness on pparg mrna expression using monozygotic twin case control |
| url | http://dx.doi.org/10.1155/2015/538732 |
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