Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016
Aims. To estimate the risk of microvascular complications and macrovascular risk factors among persons with early-onset (diagnosed at ages 0 to <5 years) and long-duration type 1 diabetes and determine temporal trends and associations with potential predictors. Methods. We conducted three populat...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7806980 |
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| author | Thaddäus Tönnies Anna Stahl-Pehe Christina Baechle Katty Castillo Oliver Kuss Rhuphine Yossa Lena M. E. Lindner Reinhard W. Holl Joachim Rosenbauer |
| author_facet | Thaddäus Tönnies Anna Stahl-Pehe Christina Baechle Katty Castillo Oliver Kuss Rhuphine Yossa Lena M. E. Lindner Reinhard W. Holl Joachim Rosenbauer |
| author_sort | Thaddäus Tönnies |
| collection | DOAJ |
| description | Aims. To estimate the risk of microvascular complications and macrovascular risk factors among persons with early-onset (diagnosed at ages 0 to <5 years) and long-duration type 1 diabetes and determine temporal trends and associations with potential predictors. Methods. We conducted three population-based cross-sectional surveys in Germany (N=1789) to obtain information on exposures and five outcomes (retinopathy, nephropathy, dyslipidemia, hypertension, and a composite endpoint combining all four outcomes). For each outcome, log-binomial spline regression was applied to estimate the risk and dose-response relationship with diabetes duration and exposures. Results. The risk for microvascular complications increased after 14 years since diabetes diagnosis whereas dyslipidemia and hypertension were already prevalent at 10 years. The 15-year risk (95% confidence interval) of the composite endpoint for female and male patients was 22.9% (18.8%–27.9%) and 19.2% (15.5%–23.8%), respectively. Temporal trends suggested a decreasing risk between 2009 and 2016. Glycemic control, lifestyle-related factors, and SES, but not health care-related factors, were associated with the risk of the composite endpoint. Conclusions. In early-onset type 1 diabetes, there exists a considerable risk of complications and comorbidities already in young ages. Future research should focus on prevention of diabetic complications in young patients and clarification of pathways of the associations found. |
| format | Article |
| id | doaj-art-fb4951c634da4ca5bd7953232fb190e2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fb4951c634da4ca5bd7953232fb190e22025-02-03T01:23:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/78069807806980Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016Thaddäus Tönnies0Anna Stahl-Pehe1Christina Baechle2Katty Castillo3Oliver Kuss4Rhuphine Yossa5Lena M. E. Lindner6Reinhard W. Holl7Joachim Rosenbauer8Institute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyGerman Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research, Heinrich Heine University, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyAims. To estimate the risk of microvascular complications and macrovascular risk factors among persons with early-onset (diagnosed at ages 0 to <5 years) and long-duration type 1 diabetes and determine temporal trends and associations with potential predictors. Methods. We conducted three population-based cross-sectional surveys in Germany (N=1789) to obtain information on exposures and five outcomes (retinopathy, nephropathy, dyslipidemia, hypertension, and a composite endpoint combining all four outcomes). For each outcome, log-binomial spline regression was applied to estimate the risk and dose-response relationship with diabetes duration and exposures. Results. The risk for microvascular complications increased after 14 years since diabetes diagnosis whereas dyslipidemia and hypertension were already prevalent at 10 years. The 15-year risk (95% confidence interval) of the composite endpoint for female and male patients was 22.9% (18.8%–27.9%) and 19.2% (15.5%–23.8%), respectively. Temporal trends suggested a decreasing risk between 2009 and 2016. Glycemic control, lifestyle-related factors, and SES, but not health care-related factors, were associated with the risk of the composite endpoint. Conclusions. In early-onset type 1 diabetes, there exists a considerable risk of complications and comorbidities already in young ages. Future research should focus on prevention of diabetic complications in young patients and clarification of pathways of the associations found.http://dx.doi.org/10.1155/2018/7806980 |
| spellingShingle | Thaddäus Tönnies Anna Stahl-Pehe Christina Baechle Katty Castillo Oliver Kuss Rhuphine Yossa Lena M. E. Lindner Reinhard W. Holl Joachim Rosenbauer Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016 International Journal of Endocrinology |
| title | Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016 |
| title_full | Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016 |
| title_fullStr | Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016 |
| title_full_unstemmed | Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016 |
| title_short | Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016 |
| title_sort | risk of microvascular complications and macrovascular risk factors in early onset type 1 diabetes after at least 10 years duration an analysis of three population based cross sectional surveys in germany between 2009 and 2016 |
| url | http://dx.doi.org/10.1155/2018/7806980 |
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