Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients
Abstract The benefit of adjuvant chemotherapy (CT) for hormone receptor-negative T1a and T1bN0M0 breast cancer remains uncertain. Our study was to explore prognostic value and identify candidates of adjuvant CT for these patients. The data of hormone receptor-negative T1a and T1bN0M0 breast cancer p...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-85434-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594873579995136 |
|---|---|
| author | Yaxiong Liu Honghui Li Jinsong Li Changlong Wei Jinsheng Zeng Qiuhong Tian |
| author_facet | Yaxiong Liu Honghui Li Jinsong Li Changlong Wei Jinsheng Zeng Qiuhong Tian |
| author_sort | Yaxiong Liu |
| collection | DOAJ |
| description | Abstract The benefit of adjuvant chemotherapy (CT) for hormone receptor-negative T1a and T1bN0M0 breast cancer remains uncertain. Our study was to explore prognostic value and identify candidates of adjuvant CT for these patients. The data of hormone receptor-negative T1a and T1bN0M0 breast cancer patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. All patients were divided into two groups according to the history of adjuvant CT namely the CT group and the no CT (No CT) group. Univariate and multivariate Cox regression analysis were utilized to identify factors linked with cancer specific survival (CSS) and overall survival (OS) for the patients. Kaplan-Meier method was employed to determine survival benefit of adjuvant CT. A total of 3889 patients were included. After propensity score-matching, 1217 patients were assigned to the CT group and 1217 patients were assigned to the No CT group respectively. Based on multivariate Cox regression analysis of OS, older age, single, T1b stage, triple-negative tumor and absence of adjuvant CT were identified as risk factors related to OS. Besides, multivariable Cox regression analysis of CSS showed significant association between grade III+IV, T1b stage, triple-negative tumor and absence of adjuvant CT and CSS. The results from Kaplan-Meier curves revealed that adjuvant CT could bring OS benefit for these patients with more than two risk factors and could improve CSS for the patients with more than one risk factor. Our study supports the implementation of individualized strategies for hormone receptor-negative T1a and T1bN0M0 breast cancer patients. Adjuvant CT was recommended for potential beneficial patients after undertaking a risk-benefit discussion. |
| format | Article |
| id | doaj-art-fb3323e4081543f8bf7a896ba7147228 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-fb3323e4081543f8bf7a896ba71472282025-01-19T12:18:34ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-85434-zPrognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patientsYaxiong Liu0Honghui Li1Jinsong Li2Changlong Wei3Jinsheng Zeng4Qiuhong Tian5Breast Disease Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityBreast Disease Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityBreast Disease Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityBreast Disease Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityBreast Disease Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract The benefit of adjuvant chemotherapy (CT) for hormone receptor-negative T1a and T1bN0M0 breast cancer remains uncertain. Our study was to explore prognostic value and identify candidates of adjuvant CT for these patients. The data of hormone receptor-negative T1a and T1bN0M0 breast cancer patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. All patients were divided into two groups according to the history of adjuvant CT namely the CT group and the no CT (No CT) group. Univariate and multivariate Cox regression analysis were utilized to identify factors linked with cancer specific survival (CSS) and overall survival (OS) for the patients. Kaplan-Meier method was employed to determine survival benefit of adjuvant CT. A total of 3889 patients were included. After propensity score-matching, 1217 patients were assigned to the CT group and 1217 patients were assigned to the No CT group respectively. Based on multivariate Cox regression analysis of OS, older age, single, T1b stage, triple-negative tumor and absence of adjuvant CT were identified as risk factors related to OS. Besides, multivariable Cox regression analysis of CSS showed significant association between grade III+IV, T1b stage, triple-negative tumor and absence of adjuvant CT and CSS. The results from Kaplan-Meier curves revealed that adjuvant CT could bring OS benefit for these patients with more than two risk factors and could improve CSS for the patients with more than one risk factor. Our study supports the implementation of individualized strategies for hormone receptor-negative T1a and T1bN0M0 breast cancer patients. Adjuvant CT was recommended for potential beneficial patients after undertaking a risk-benefit discussion.https://doi.org/10.1038/s41598-025-85434-zSurvival benefitAdjuvant chemotherapyHormone receptor-negativeT1a and T1bN0M0 breast cancer patients |
| spellingShingle | Yaxiong Liu Honghui Li Jinsong Li Changlong Wei Jinsheng Zeng Qiuhong Tian Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients Scientific Reports Survival benefit Adjuvant chemotherapy Hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| title | Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| title_full | Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| title_fullStr | Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| title_full_unstemmed | Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| title_short | Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| title_sort | prognostic value of adjuvant chemotherapy for hormone receptor negative t1a and t1bn0m0 breast cancer patients |
| topic | Survival benefit Adjuvant chemotherapy Hormone receptor-negative T1a and T1bN0M0 breast cancer patients |
| url | https://doi.org/10.1038/s41598-025-85434-z |
| work_keys_str_mv | AT yaxiongliu prognosticvalueofadjuvantchemotherapyforhormonereceptornegativet1aandt1bn0m0breastcancerpatients AT honghuili prognosticvalueofadjuvantchemotherapyforhormonereceptornegativet1aandt1bn0m0breastcancerpatients AT jinsongli prognosticvalueofadjuvantchemotherapyforhormonereceptornegativet1aandt1bn0m0breastcancerpatients AT changlongwei prognosticvalueofadjuvantchemotherapyforhormonereceptornegativet1aandt1bn0m0breastcancerpatients AT jinshengzeng prognosticvalueofadjuvantchemotherapyforhormonereceptornegativet1aandt1bn0m0breastcancerpatients AT qiuhongtian prognosticvalueofadjuvantchemotherapyforhormonereceptornegativet1aandt1bn0m0breastcancerpatients |