Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age
Kawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD is from 6 months to 5 years of age, and the incidence is unusual in those younger than 6 months and older than 5 years of age. We tried to identify genetic variants spe...
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BioMed Central
2018-06-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2018-16-2-36.pdf |
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| author | Hea-Ji Kim Sin Weon Yun Jeong Jin Yu Kyung Lim Yoon Kyung-Yil Lee Hong-Ryang Kil Gi Beom Kim Myung-Ki Han Min Seob Song Hyoung Doo Lee Kee Soo Ha Sejung Sohn Ryota Ebata Hiromichi Hamada Hiroyuki Suzuki Yoichiro Kamatani Michiaki Kubo Kaoru Ito Yoshihiro Onouchi Young Mi Hong Gi Young Jang Jong-Keuk Lee |
| author_facet | Hea-Ji Kim Sin Weon Yun Jeong Jin Yu Kyung Lim Yoon Kyung-Yil Lee Hong-Ryang Kil Gi Beom Kim Myung-Ki Han Min Seob Song Hyoung Doo Lee Kee Soo Ha Sejung Sohn Ryota Ebata Hiromichi Hamada Hiroyuki Suzuki Yoichiro Kamatani Michiaki Kubo Kaoru Ito Yoshihiro Onouchi Young Mi Hong Gi Young Jang Jong-Keuk Lee |
| author_sort | Hea-Ji Kim |
| collection | DOAJ |
| description | Kawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD is from 6 months to 5 years of age, and the incidence is unusual in those younger than 6 months and older than 5 years of age. We tried to identify genetic variants specifically associated with KD in patients younger than 6 months or older than 5 years of age. We performed an age-stratified genome-wide association study using the Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) and a replication study (1,360 cases vs. 3,553 controls) in the Korean population. Among 26 candidate single nucleotide polymorphisms (SNPs) tested in replication study, only a rare nonsynonymous SNP (rs4365796: c.1106C＞T, p.Thr369Met) in the lymphoid enhancer binding factor 1 (LEF1) gene was very significantly associated with KD in patients younger than 6 months of age (odds ratio [OR], 3.07; pcombined = 1.10 × 10-5), whereas no association of the same SNP was observed in any other age group of KD patients. The same SNP (rs4365796) in the LEF1 gene showed the same direction of risk effect in Japanese KD patients younger than 6 months of age, although the effect was not statistically significant (OR, 1.42; p = 0.397). This result indicates that the LEF1 gene may play an important role as a susceptibility gene specifically affecting KD patients younger than 6 months of age. |
| format | Article |
| id | doaj-art-fb2e4c2ddfc34de5bc6cdc8012fe1fa7 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-fb2e4c2ddfc34de5bc6cdc8012fe1fa72025-02-02T06:08:11ZengBioMed CentralGenomics & Informatics2234-07422018-06-01162364110.5808/GI.2018.16.2.36510Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of AgeHea-Ji Kim0Sin Weon Yun1Jeong Jin Yu2Kyung Lim Yoon3Kyung-Yil Lee4Hong-Ryang Kil5Gi Beom Kim6Myung-Ki Han7Min Seob Song8Hyoung Doo Lee9Kee Soo Ha10Sejung Sohn11Ryota Ebata12Hiromichi Hamada13Hiroyuki Suzuki14Yoichiro Kamatani15Michiaki Kubo16Kaoru Ito17Yoshihiro Onouchi18Young Mi Hong19Gi Young Jang20Jong-Keuk Lee21 Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 05505, Korea Department of Pediatrics, Chung-Ang University Hospital, Seoul 06973, Korea Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea Department of Pediatrics, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea Department of Pediatrics, Chungnam National University Hospital, Daejeon 35015, Korea Department of Pediatrics, Seoul National University Children’s Hospital, Seoul 03080, Korea Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea Department of Pediatrics, Inje University Busan Paik Hospital, Busan 47392, Korea Department of Pediatrics, Pusan National University Hospital, Busan 49241, Korea Department of Pediatrics, Korea University Ansan Hospital, Ansan 15355, Korea Department of Pediatrics, Ewha Womans University Hospital, Seoul 07985, Korea Department of Pediatrics, Chiba-University Graduate School of Medicine, Chiba 260-8670, Japan Department of Pediatrics, Tokyo Women’s Medical University Yachivo Medical Center, Yachivo 276-8524, Japan Department of Pediatrics, Wakayama Medical University, Wakayama 641-8509, Japan Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan Department of Pediatrics, Ewha Womans University Hospital, Seoul 07985, Korea Department of Pediatrics, Korea University Ansan Hospital, Ansan 15355, Korea Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 05505, KoreaKawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD is from 6 months to 5 years of age, and the incidence is unusual in those younger than 6 months and older than 5 years of age. We tried to identify genetic variants specifically associated with KD in patients younger than 6 months or older than 5 years of age. We performed an age-stratified genome-wide association study using the Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) and a replication study (1,360 cases vs. 3,553 controls) in the Korean population. Among 26 candidate single nucleotide polymorphisms (SNPs) tested in replication study, only a rare nonsynonymous SNP (rs4365796: c.1106C＞T, p.Thr369Met) in the lymphoid enhancer binding factor 1 (LEF1) gene was very significantly associated with KD in patients younger than 6 months of age (odds ratio [OR], 3.07; pcombined = 1.10 × 10-5), whereas no association of the same SNP was observed in any other age group of KD patients. The same SNP (rs4365796) in the LEF1 gene showed the same direction of risk effect in Japanese KD patients younger than 6 months of age, although the effect was not statistically significant (OR, 1.42; p = 0.397). This result indicates that the LEF1 gene may play an important role as a susceptibility gene specifically affecting KD patients younger than 6 months of age.http://genominfo.org/upload/pdf/gi-2018-16-2-36.pdfgenome-wide association studyKawasaki diseaselymphoid enhancer binding factor1 ()single nucleotide polymorphism |
| spellingShingle | Hea-Ji Kim Sin Weon Yun Jeong Jin Yu Kyung Lim Yoon Kyung-Yil Lee Hong-Ryang Kil Gi Beom Kim Myung-Ki Han Min Seob Song Hyoung Doo Lee Kee Soo Ha Sejung Sohn Ryota Ebata Hiromichi Hamada Hiroyuki Suzuki Yoichiro Kamatani Michiaki Kubo Kaoru Ito Yoshihiro Onouchi Young Mi Hong Gi Young Jang Jong-Keuk Lee Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age Genomics & Informatics genome-wide association study Kawasaki disease lymphoid enhancer binding factor1 () single nucleotide polymorphism |
| title | Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age |
| title_full | Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age |
| title_fullStr | Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age |
| title_full_unstemmed | Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age |
| title_short | Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age |
| title_sort | identification of as a susceptibility locus for kawasaki disease in patients younger than 6 months of age |
| topic | genome-wide association study Kawasaki disease lymphoid enhancer binding factor1 () single nucleotide polymorphism |
| url | http://genominfo.org/upload/pdf/gi-2018-16-2-36.pdf |
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