Interferons and Interferon Regulatory Factors in Malaria
Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent whi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/243713 |
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| _version_ | 1832563260642033664 |
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| author | Sin Yee Gun Carla Claser Kevin Shyong Wei Tan Laurent Rénia |
| author_facet | Sin Yee Gun Carla Claser Kevin Shyong Wei Tan Laurent Rénia |
| author_sort | Sin Yee Gun |
| collection | DOAJ |
| description | Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. However, a minority of these can become severe and life-threatening, manifesting a range of overlapping syndromes of complex origins which could be induced by uncontrolled immune responses. Major players of the innate and adaptive responses are interferons. Here, we review their roles and the signaling pathways involved in their production and protection against infection and induced immunopathologies. |
| format | Article |
| id | doaj-art-fb23a889cff14baf87d06130f41410ca |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fb23a889cff14baf87d06130f41410ca2025-02-03T01:20:42ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/243713243713Interferons and Interferon Regulatory Factors in MalariaSin Yee Gun0Carla Claser1Kevin Shyong Wei Tan2Laurent Rénia3Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 138648, SingaporeSingapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 138648, SingaporeDepartment of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, SingaporeSingapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 138648, SingaporeMalaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. However, a minority of these can become severe and life-threatening, manifesting a range of overlapping syndromes of complex origins which could be induced by uncontrolled immune responses. Major players of the innate and adaptive responses are interferons. Here, we review their roles and the signaling pathways involved in their production and protection against infection and induced immunopathologies.http://dx.doi.org/10.1155/2014/243713 |
| spellingShingle | Sin Yee Gun Carla Claser Kevin Shyong Wei Tan Laurent Rénia Interferons and Interferon Regulatory Factors in Malaria Mediators of Inflammation |
| title | Interferons and Interferon Regulatory Factors in Malaria |
| title_full | Interferons and Interferon Regulatory Factors in Malaria |
| title_fullStr | Interferons and Interferon Regulatory Factors in Malaria |
| title_full_unstemmed | Interferons and Interferon Regulatory Factors in Malaria |
| title_short | Interferons and Interferon Regulatory Factors in Malaria |
| title_sort | interferons and interferon regulatory factors in malaria |
| url | http://dx.doi.org/10.1155/2014/243713 |
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