Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice
Spermatogenesis is a complex mechanism which allows the production of male gametes; it consists of mitotic, meiotic, and differentiation phases. Spermiogenesis is the terminal differentiation process during which haploid round spermatids undergo several biochemical and morphological changes, includi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/501350 |
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| author | Giovanna Cacciola Teresa Chioccarelli Silvia Fasano Riccardo Pierantoni Gilda Cobellis |
| author_facet | Giovanna Cacciola Teresa Chioccarelli Silvia Fasano Riccardo Pierantoni Gilda Cobellis |
| author_sort | Giovanna Cacciola |
| collection | DOAJ |
| description | Spermatogenesis is a complex mechanism which allows the production of male gametes; it consists of mitotic, meiotic, and differentiation phases. Spermiogenesis is the terminal differentiation process during which haploid round spermatids undergo several biochemical and morphological changes, including extensive remodelling of chromatin and nuclear shape. Spermiogenesis is under control of endocrine, paracrine, and autocrine factors, like gonadotropins and testosterone. More recently, emerging pieces of evidence are suggesting that, among these factors, estrogens may have a role. To date, this is a matter of debate and concern because of the agonistic and antagonistic estrogenic effects that environmental chemicals may have on animal and human with damaging outcome on fertility. In this review, we summarize data which fuel this debate, with a particular attention to our recent results, obtained using type 1 cannabinoid receptor knockout male mice as animal model. |
| format | Article |
| id | doaj-art-fb2214319a634c78bad30b718570af7a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fb2214319a634c78bad30b718570af7a2025-02-03T01:26:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/501350501350Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout MiceGiovanna Cacciola0Teresa Chioccarelli1Silvia Fasano2Riccardo Pierantoni3Gilda Cobellis4Dipartimento di Medicina Sperimentale, Sez. Bottazzi, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, ItalyDipartimento di Medicina Sperimentale, Sez. Bottazzi, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, ItalyDipartimento di Medicina Sperimentale, Sez. Bottazzi, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, ItalyDipartimento di Medicina Sperimentale, Sez. Bottazzi, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, ItalyDipartimento di Medicina Sperimentale, Sez. Bottazzi, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, ItalySpermatogenesis is a complex mechanism which allows the production of male gametes; it consists of mitotic, meiotic, and differentiation phases. Spermiogenesis is the terminal differentiation process during which haploid round spermatids undergo several biochemical and morphological changes, including extensive remodelling of chromatin and nuclear shape. Spermiogenesis is under control of endocrine, paracrine, and autocrine factors, like gonadotropins and testosterone. More recently, emerging pieces of evidence are suggesting that, among these factors, estrogens may have a role. To date, this is a matter of debate and concern because of the agonistic and antagonistic estrogenic effects that environmental chemicals may have on animal and human with damaging outcome on fertility. In this review, we summarize data which fuel this debate, with a particular attention to our recent results, obtained using type 1 cannabinoid receptor knockout male mice as animal model.http://dx.doi.org/10.1155/2013/501350 |
| spellingShingle | Giovanna Cacciola Teresa Chioccarelli Silvia Fasano Riccardo Pierantoni Gilda Cobellis Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice International Journal of Endocrinology |
| title | Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice |
| title_full | Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice |
| title_fullStr | Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice |
| title_full_unstemmed | Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice |
| title_short | Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice |
| title_sort | estrogens and spermiogenesis new insights from type 1 cannabinoid receptor knockout mice |
| url | http://dx.doi.org/10.1155/2013/501350 |
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