FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis
Purpose Multiple sclerosis (MS) is an immune-mediated, neuroinflammatory disease of the central nervous system and in industrialised countries is the most common cause of progressive neurological disability in working age persons. While treatable, there is substantial interindividual heterogeneity i...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e058506.full |
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| author | David Hunt Siddharthan Chandran Peter Connick Peter Foley Patrick K A Kearns Sergio E Baranzini Adam D Waldman Sarah J Martin Elizabeth Freyer F J Carod-Artal Lee Murphy Amy Stenson Jessie Chang Rozanna Meijboom Elizabeth N York Yingdi Chen Christine Weaver Katarzyna Hafezi Stacey Thomson Adil Harroud Margaret McLeod Jonathon O'Riordan Niall J J MacDougall |
| author_facet | David Hunt Siddharthan Chandran Peter Connick Peter Foley Patrick K A Kearns Sergio E Baranzini Adam D Waldman Sarah J Martin Elizabeth Freyer F J Carod-Artal Lee Murphy Amy Stenson Jessie Chang Rozanna Meijboom Elizabeth N York Yingdi Chen Christine Weaver Katarzyna Hafezi Stacey Thomson Adil Harroud Margaret McLeod Jonathon O'Riordan Niall J J MacDougall |
| author_sort | David Hunt |
| collection | DOAJ |
| description | Purpose Multiple sclerosis (MS) is an immune-mediated, neuroinflammatory disease of the central nervous system and in industrialised countries is the most common cause of progressive neurological disability in working age persons. While treatable, there is substantial interindividual heterogeneity in disease activity and response to treatment. Currently, the ability to predict at diagnosis who will have a benign, intermediate or aggressive disease course is very limited. There is, therefore, a need for integrated predictive tools to inform individualised treatment decision making.Participants Established with the aim of addressing this need for individualised predictive tools, FutureMS is a nationally representative, prospective observational cohort study of 440 adults with a new diagnosis of relapsing-remitting MS living in Scotland at the time of diagnosis between May 2016 and March 2019.Findings to date The study aims to explore the pathobiology and determinants of disease heterogeneity in MS and combines detailed clinical phenotyping with imaging, genetic and biomarker metrics of disease activity and progression. Recruitment, baseline assessment and follow-up at year 1 is complete. Here, we describe the cohort design and present a profile of the participants at baseline and 1 year of follow-up.Future plans A third follow-up wave for the cohort has recently begun at 5 years after first visit and a further wave of follow-up is funded for year 10. Longer-term follow-up is anticipated thereafter. |
| format | Article |
| id | doaj-art-fb201fb570b44c7b91f695092b5dacff |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-fb201fb570b44c7b91f695092b5dacff2025-01-28T13:05:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-058506FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosisDavid Hunt0Siddharthan Chandran1Peter Connick2Peter Foley3Patrick K A Kearns4Sergio E Baranzini5Adam D Waldman6Sarah J Martin7Elizabeth Freyer8F J Carod-Artal9Lee Murphy10Amy Stenson11Jessie Chang12Rozanna Meijboom13Elizabeth N York14Yingdi Chen15Christine Weaver16Katarzyna Hafezi17Stacey Thomson18Adil Harroud19Margaret McLeod20Jonathon O'Riordan21Niall J J MacDougall22Anne Rowling Regenerative Neurology Clinic, The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UK3 The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, Edinburgh, UK3 The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, Edinburgh, UKAnne Rowling Regenerative Neurology Clinic, The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UKAnne Rowling Regenerative Neurology Clinic, The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UKDepartment of Neurology, Weill Institute of Clinical Neuroscience, San Francisco, California, USACentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UKInstitute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UKDepartment of Neurology, Raigmore Hospital, Inverness, UKEdinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UKCentre for Exercise and Rehabilitation Science, Pulmonary Rehabilitation Department, University Hospitals of Leicester NHS Trust, Leicester, UKAnne Rowling Regenerative Neurology Clinic, The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UKCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKThe Anne Rowling Regenerative Neurology Clinic, The University of Edinburgh, EdinburghUKWellcome Trust Clinical Research Facility, Edinburgh, UKInstitute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UKDepartment of Neurology, Weill Institute of Clinical Neuroscience, San Francisco, California, USADepartment of Neurology, Aberdeen Royal Infirmary, Aberdeen, UKTayside Centre for Clinical Neurosciences, University of Dundee Division of Neuroscience, Dundee, UKAnne Rowling Regenerative Neurology Clinic, The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UKPurpose Multiple sclerosis (MS) is an immune-mediated, neuroinflammatory disease of the central nervous system and in industrialised countries is the most common cause of progressive neurological disability in working age persons. While treatable, there is substantial interindividual heterogeneity in disease activity and response to treatment. Currently, the ability to predict at diagnosis who will have a benign, intermediate or aggressive disease course is very limited. There is, therefore, a need for integrated predictive tools to inform individualised treatment decision making.Participants Established with the aim of addressing this need for individualised predictive tools, FutureMS is a nationally representative, prospective observational cohort study of 440 adults with a new diagnosis of relapsing-remitting MS living in Scotland at the time of diagnosis between May 2016 and March 2019.Findings to date The study aims to explore the pathobiology and determinants of disease heterogeneity in MS and combines detailed clinical phenotyping with imaging, genetic and biomarker metrics of disease activity and progression. Recruitment, baseline assessment and follow-up at year 1 is complete. Here, we describe the cohort design and present a profile of the participants at baseline and 1 year of follow-up.Future plans A third follow-up wave for the cohort has recently begun at 5 years after first visit and a further wave of follow-up is funded for year 10. Longer-term follow-up is anticipated thereafter.https://bmjopen.bmj.com/content/12/6/e058506.full |
| spellingShingle | David Hunt Siddharthan Chandran Peter Connick Peter Foley Patrick K A Kearns Sergio E Baranzini Adam D Waldman Sarah J Martin Elizabeth Freyer F J Carod-Artal Lee Murphy Amy Stenson Jessie Chang Rozanna Meijboom Elizabeth N York Yingdi Chen Christine Weaver Katarzyna Hafezi Stacey Thomson Adil Harroud Margaret McLeod Jonathon O'Riordan Niall J J MacDougall FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis BMJ Open |
| title | FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis |
| title_full | FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis |
| title_fullStr | FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis |
| title_full_unstemmed | FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis |
| title_short | FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis |
| title_sort | futurems cohort profile a scottish multicentre inception cohort study of relapsing remitting multiple sclerosis |
| url | https://bmjopen.bmj.com/content/12/6/e058506.full |
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