Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine
Immunology advances have increased our understanding of autoimmune, auto-inflammatory, immunodeficiency, infectious, and other immune-mediated inflammatory diseases (IMIDs). Furthermore, evidence is growing for the immune involvement in aging, metabolic and neurodegenerative diseases, and different...
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IMR Press
2025-01-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL27118 |
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| author | Vijay Kumar |
| author_facet | Vijay Kumar |
| author_sort | Vijay Kumar |
| collection | DOAJ |
| description | Immunology advances have increased our understanding of autoimmune, auto-inflammatory, immunodeficiency, infectious, and other immune-mediated inflammatory diseases (IMIDs). Furthermore, evidence is growing for the immune involvement in aging, metabolic and neurodegenerative diseases, and different cancers. However, further research has indicated sex/gender-based immune differences, which further increase higher incidences of various autoimmune diseases (AIDs), such as systemic lupus erythematosus (SLE), myasthenia gravis, and rheumatoid arthritis (RA) in females. On the other hand, reproductive-age females also show a more potent immune response against infections and vaccines than their age-matched males—furthermore, some immune-based therapies, including immune checkpoint inhibitors (ICIs), show gender-based efficacy and adverse events. Metabolic demands are different in males and females. Immune cell function and polarization are also governed by their metabolic reprogramming, called immunometabolism and immunometabolic reprogramming (IR). Therefore, sex/gender-associated immune differences and their involvement in immune-mediated diseases and immune-based therapeutics indicate the demand for gender-based IR studies to increase the efficacy of immune-based precision medicine. |
| format | Article |
| id | doaj-art-fb2013b889c34e3c89b3d3084116f04e |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-fb2013b889c34e3c89b3d3084116f04e2025-01-25T08:55:52ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-01-013012711810.31083/FBL27118S2768-6701(24)01582-XIgnoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision MedicineVijay Kumar0Department of Surgery, Laboratory of Tumor Immunology and Immunotherapy, Morehouse School of Medicine, Atlanta, GA 30310, USAImmunology advances have increased our understanding of autoimmune, auto-inflammatory, immunodeficiency, infectious, and other immune-mediated inflammatory diseases (IMIDs). Furthermore, evidence is growing for the immune involvement in aging, metabolic and neurodegenerative diseases, and different cancers. However, further research has indicated sex/gender-based immune differences, which further increase higher incidences of various autoimmune diseases (AIDs), such as systemic lupus erythematosus (SLE), myasthenia gravis, and rheumatoid arthritis (RA) in females. On the other hand, reproductive-age females also show a more potent immune response against infections and vaccines than their age-matched males—furthermore, some immune-based therapies, including immune checkpoint inhibitors (ICIs), show gender-based efficacy and adverse events. Metabolic demands are different in males and females. Immune cell function and polarization are also governed by their metabolic reprogramming, called immunometabolism and immunometabolic reprogramming (IR). Therefore, sex/gender-associated immune differences and their involvement in immune-mediated diseases and immune-based therapeutics indicate the demand for gender-based IR studies to increase the efficacy of immune-based precision medicine.https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL27118sex/genderimmunometabolismimmunometabolic reprogramingimmune cellsprrs |
| spellingShingle | Vijay Kumar Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine Frontiers in Bioscience-Landmark sex/gender immunometabolism immunometabolic reprograming immune cells prrs |
| title | Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine |
| title_full | Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine |
| title_fullStr | Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine |
| title_full_unstemmed | Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine |
| title_short | Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine |
| title_sort | ignoring gender based immunometabolic reprograming a risky business in immune based precision medicine |
| topic | sex/gender immunometabolism immunometabolic reprograming immune cells prrs |
| url | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL27118 |
| work_keys_str_mv | AT vijaykumar ignoringgenderbasedimmunometabolicreprogramingariskybusinessinimmunebasedprecisionmedicine |