Polydatin-curcumin formulation alleviates CTD-ILD-like lung injury in mice via GABBR/PI3K/AKT/TGF-β pathway

Polydatin-curcumin formulation alleviates CTD-ILD-like lung injury in mice via GABBR/PI3K/AKT/TGF-β pathway

Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a systemic autoimmune disease with high morbidity and hazard, characterized by progressive pulmonary inflammation and fibrosis. The monomer formulation of polydatin and curcumin (PD + Cur) for lung injury in CTD-ILD was opti...

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Bibliographic Details
Main Authors: Zhengju Zhang, Yao Zhang, Qingyi Lu, Yanan Wang, Guodong Li, Guoju Jin, Weiguo Ma, Yuyue Liu, Lei Yang, Hui Liu, Honghong Zhang, Wen Gu, Xinqi Deng, Chunguo Wang, Fengxian Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
CTD-ILD
polydatin
curcumin
GABBR
PI3K/AKT/TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1573525/full
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