Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation
The emerging field of vascular composite allotransplantation (VCA) has become a clinical reality. Building upon cutting edge understandings of transplant surgery and immunology, complex grafts such as hands and faces can now be transplanted with success. Many of the challenges that have historically...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/402980 |
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| author | Ravi Starzl Gerald Brandacher W. P. Andrew Lee Jaime Carbonell Wensheng Zhang Jonas Schnider Vijay Gorantla Stefan Schneeberger Xin Xiao Zheng |
| author_facet | Ravi Starzl Gerald Brandacher W. P. Andrew Lee Jaime Carbonell Wensheng Zhang Jonas Schnider Vijay Gorantla Stefan Schneeberger Xin Xiao Zheng |
| author_sort | Ravi Starzl |
| collection | DOAJ |
| description | The emerging field of vascular composite allotransplantation (VCA) has become a clinical reality. Building upon cutting edge understandings of transplant surgery and immunology, complex grafts such as hands and faces can now be transplanted with success. Many of the challenges that have historically been limiting factors in transplantation, such as rejection and the morbidity of immunosuppression, remain challenges in VCA. Because of the accessibility of most VCA grafts, and the highly immunogenic nature of the skin in particular, VCA has become the focal point for cross-disciplinary approaches to developing novel approaches for some of the most challenging immunological problems in transplantation, particularly the early diagnoses and assessment of rejection. This paper provides a historically oriented introduction to the field of organ transplantation and the evolution of VCA. |
| format | Article |
| id | doaj-art-fb1e2c6224c54fd0b2da99abfce8cdf4 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-fb1e2c6224c54fd0b2da99abfce8cdf42025-02-03T05:44:40ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/402980402980Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite AllotransplantationRavi Starzl0Gerald Brandacher1W. P. Andrew Lee2Jaime Carbonell3Wensheng Zhang4Jonas Schnider5Vijay Gorantla6Stefan Schneeberger7Xin Xiao Zheng8Language Technologies Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USADepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21287, USADepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21287, USALanguage Technologies Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USADepartment of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21287, USADepartment of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USAThe emerging field of vascular composite allotransplantation (VCA) has become a clinical reality. Building upon cutting edge understandings of transplant surgery and immunology, complex grafts such as hands and faces can now be transplanted with success. Many of the challenges that have historically been limiting factors in transplantation, such as rejection and the morbidity of immunosuppression, remain challenges in VCA. Because of the accessibility of most VCA grafts, and the highly immunogenic nature of the skin in particular, VCA has become the focal point for cross-disciplinary approaches to developing novel approaches for some of the most challenging immunological problems in transplantation, particularly the early diagnoses and assessment of rejection. This paper provides a historically oriented introduction to the field of organ transplantation and the evolution of VCA.http://dx.doi.org/10.1155/2013/402980 |
| spellingShingle | Ravi Starzl Gerald Brandacher W. P. Andrew Lee Jaime Carbonell Wensheng Zhang Jonas Schnider Vijay Gorantla Stefan Schneeberger Xin Xiao Zheng Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation Clinical and Developmental Immunology |
| title | Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation |
| title_full | Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation |
| title_fullStr | Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation |
| title_full_unstemmed | Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation |
| title_short | Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation |
| title_sort | review of the early diagnoses and assessment of rejection in vascularized composite allotransplantation |
| url | http://dx.doi.org/10.1155/2013/402980 |
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