The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol
Abstract Background Perilunate spectrum injuries (PSI) are uncommon, but high-energy injuries that result in significant functional implications for patients. The existing literature on PSI is limited to small case-series and there are no evidence-based guidelines for management. Methods This manusc...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-024-08227-x |
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| author | Eric C. Mitchell Isabelle Tottenham Ruby Grewal Matthew W. T. Curran Neil J. White |
| author_facet | Eric C. Mitchell Isabelle Tottenham Ruby Grewal Matthew W. T. Curran Neil J. White |
| author_sort | Eric C. Mitchell |
| collection | DOAJ |
| description | Abstract Background Perilunate spectrum injuries (PSI) are uncommon, but high-energy injuries that result in significant functional implications for patients. The existing literature on PSI is limited to small case-series and there are no evidence-based guidelines for management. Methods This manuscript outlines a protocol for a three-armed, national, multi-centre study, which includes a patient injury registry for PSI, as well as associated retrospective and prospective arms. The primary objective is to establish a national injury registry for patients who present with PSI. The secondary objectives are to examine the long-term clinical and radiographic outcomes of PSI, evaluate progression of these outcomes over time, and to examine the impact of specific operative and injury related factors on outcomes. Discussion This paper describes the protocol for a three-armed, multi-centre study of PSI. It outlines the rationale for the study as well as the relevant methodological details. An injury registry involving multiple centres is valuable given this is an uncommon injury with many potential variables affecting outcomes. Registry-based retrospective and prospective studies will benefit from the large clinical database provided by the registry and could be used to guide evidence-based treatment guidelines which are currently lacking in the literature. Trial registration Clinicaltrials.gov identifier: NCT04370626. |
| format | Article |
| id | doaj-art-fb1311aba65b4654af854ea7a4798143 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-fb1311aba65b4654af854ea7a47981432025-02-02T12:05:37ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-012611610.1186/s12891-024-08227-xThe Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocolEric C. Mitchell0Isabelle Tottenham1Ruby Grewal2Matthew W. T. Curran3Neil J. White4Division of Plastic Surgery, Western UniversityCumming School of Medicine, University of CalgaryDivision of Orthopedic Surgery, Roth, cFMarlane Hand & Upper Limb Center, St Joseph’s Health CareDivision of Plastic Surgery, University of AlbertaDivision of Orthopedic Surgery, University of CalgaryAbstract Background Perilunate spectrum injuries (PSI) are uncommon, but high-energy injuries that result in significant functional implications for patients. The existing literature on PSI is limited to small case-series and there are no evidence-based guidelines for management. Methods This manuscript outlines a protocol for a three-armed, national, multi-centre study, which includes a patient injury registry for PSI, as well as associated retrospective and prospective arms. The primary objective is to establish a national injury registry for patients who present with PSI. The secondary objectives are to examine the long-term clinical and radiographic outcomes of PSI, evaluate progression of these outcomes over time, and to examine the impact of specific operative and injury related factors on outcomes. Discussion This paper describes the protocol for a three-armed, multi-centre study of PSI. It outlines the rationale for the study as well as the relevant methodological details. An injury registry involving multiple centres is valuable given this is an uncommon injury with many potential variables affecting outcomes. Registry-based retrospective and prospective studies will benefit from the large clinical database provided by the registry and could be used to guide evidence-based treatment guidelines which are currently lacking in the literature. Trial registration Clinicaltrials.gov identifier: NCT04370626.https://doi.org/10.1186/s12891-024-08227-xWristPerilunate dislocationPerilunate fracture-dislocationOperative treatment |
| spellingShingle | Eric C. Mitchell Isabelle Tottenham Ruby Grewal Matthew W. T. Curran Neil J. White The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol BMC Musculoskeletal Disorders Wrist Perilunate dislocation Perilunate fracture-dislocation Operative treatment |
| title | The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol |
| title_full | The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol |
| title_fullStr | The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol |
| title_full_unstemmed | The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol |
| title_short | The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol |
| title_sort | canadian prospective pragmatic perilunate outcomes c3po trial a protocol |
| topic | Wrist Perilunate dislocation Perilunate fracture-dislocation Operative treatment |
| url | https://doi.org/10.1186/s12891-024-08227-x |
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