Regulatory role of S1P and its receptors in sepsis-induced liver injury
As an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphi...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1489015/full |
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| author | Bin Wang Bin Wang Xiaoyu Wu Xiaoyu Wu Jiangfeng Cheng Jiangfeng Cheng Junming Ye Junming Ye Hongquan Zhu Hongquan Zhu Xiaofeng Liu Xiaofeng Liu |
| author_facet | Bin Wang Bin Wang Xiaoyu Wu Xiaoyu Wu Jiangfeng Cheng Jiangfeng Cheng Junming Ye Junming Ye Hongquan Zhu Hongquan Zhu Xiaofeng Liu Xiaofeng Liu |
| author_sort | Bin Wang |
| collection | DOAJ |
| description | As an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) to regulate downstream signaling pathways involved in the pathophysiological processes of sepsis, including endothelial permeability, cytokine release, and vascular tone. This review summarizes current research on the role of S1P in normal liver biology and describes the mechanisms by which changes in S1P/S1PR affect the development of liver-related diseases. At the same time, the pathological processes underlying liver injury, as evidenced by clinical manifestations during sepsis, were comprehensively reviewed. This paper focused on the mechanistic pathways through which S1P and its receptors modulate immunity, bile acid metabolism, and liver-intestinal circulation in septic liver injury. Finally, the relationships between S1P and its receptors with liver inflammation and metabolism and the use of related drugs for the treatment of liver injury were examined. By elucidating the role of S1P and its receptor in the pathogenesis of sepsis liver injury, this review established a molecular targeting framework, providing novel insights into clinical and drug development. |
| format | Article |
| id | doaj-art-fafeb0ca3513432a90473b16d716a4db |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-fafeb0ca3513432a90473b16d716a4db2025-01-28T06:41:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14890151489015Regulatory role of S1P and its receptors in sepsis-induced liver injuryBin Wang0Bin Wang1Xiaoyu Wu2Xiaoyu Wu3Jiangfeng Cheng4Jiangfeng Cheng5Junming Ye6Junming Ye7Hongquan Zhu8Hongquan Zhu9Xiaofeng Liu10Xiaofeng Liu11The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaClinical College, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaClinical College, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Emergency, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaAs an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) to regulate downstream signaling pathways involved in the pathophysiological processes of sepsis, including endothelial permeability, cytokine release, and vascular tone. This review summarizes current research on the role of S1P in normal liver biology and describes the mechanisms by which changes in S1P/S1PR affect the development of liver-related diseases. At the same time, the pathological processes underlying liver injury, as evidenced by clinical manifestations during sepsis, were comprehensively reviewed. This paper focused on the mechanistic pathways through which S1P and its receptors modulate immunity, bile acid metabolism, and liver-intestinal circulation in septic liver injury. Finally, the relationships between S1P and its receptors with liver inflammation and metabolism and the use of related drugs for the treatment of liver injury were examined. By elucidating the role of S1P and its receptor in the pathogenesis of sepsis liver injury, this review established a molecular targeting framework, providing novel insights into clinical and drug development.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1489015/fullS1PS1PRssepsisimmunebile acid metabolismliver-intestinal circulation |
| spellingShingle | Bin Wang Bin Wang Xiaoyu Wu Xiaoyu Wu Jiangfeng Cheng Jiangfeng Cheng Junming Ye Junming Ye Hongquan Zhu Hongquan Zhu Xiaofeng Liu Xiaofeng Liu Regulatory role of S1P and its receptors in sepsis-induced liver injury Frontiers in Immunology S1P S1PRs sepsis immune bile acid metabolism liver-intestinal circulation |
| title | Regulatory role of S1P and its receptors in sepsis-induced liver injury |
| title_full | Regulatory role of S1P and its receptors in sepsis-induced liver injury |
| title_fullStr | Regulatory role of S1P and its receptors in sepsis-induced liver injury |
| title_full_unstemmed | Regulatory role of S1P and its receptors in sepsis-induced liver injury |
| title_short | Regulatory role of S1P and its receptors in sepsis-induced liver injury |
| title_sort | regulatory role of s1p and its receptors in sepsis induced liver injury |
| topic | S1P S1PRs sepsis immune bile acid metabolism liver-intestinal circulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1489015/full |
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