Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation
From quiescence to activation and myogenic differentiation, muscle stem cells (MuSCs) experience drastic alterations in their signaling activity and metabolism. Through balanced cycles of fission and fusion, mitochondria alter their morphology and metabolism, allowing them to affect their decisive r...
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MDPI AG
2024-10-01
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| Online Access: | https://www.mdpi.com/2073-4409/13/21/1773 |
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| author | Olivia Sommers Rholls A. Tomsine Mireille Khacho |
| author_facet | Olivia Sommers Rholls A. Tomsine Mireille Khacho |
| author_sort | Olivia Sommers |
| collection | DOAJ |
| description | From quiescence to activation and myogenic differentiation, muscle stem cells (MuSCs) experience drastic alterations in their signaling activity and metabolism. Through balanced cycles of fission and fusion, mitochondria alter their morphology and metabolism, allowing them to affect their decisive role in modulating MuSC activity and fate decisions. This tightly regulated process contributes to MuSC regulation by mediating changes in redox signaling pathways, cell cycle progression, and cell fate decisions. In this review, we discuss the role of mitochondrial dynamics as an integral modulator of MuSC activity, fate, and maintenance. Understanding the influence of mitochondrial dynamics in MuSCs in health and disease will further the development of therapeutics that support MuSC integrity and thus may aid in restoring the regenerative capacity of skeletal muscle. |
| format | Article |
| id | doaj-art-fafb51b0a6fc4a109961d9fa0db1dd30 |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-fafb51b0a6fc4a109961d9fa0db1dd302025-08-20T02:49:49ZengMDPI AGCells2073-44092024-10-011321177310.3390/cells13211773Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic DifferentiationOlivia Sommers0Rholls A. Tomsine1Mireille Khacho2Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaFrom quiescence to activation and myogenic differentiation, muscle stem cells (MuSCs) experience drastic alterations in their signaling activity and metabolism. Through balanced cycles of fission and fusion, mitochondria alter their morphology and metabolism, allowing them to affect their decisive role in modulating MuSC activity and fate decisions. This tightly regulated process contributes to MuSC regulation by mediating changes in redox signaling pathways, cell cycle progression, and cell fate decisions. In this review, we discuss the role of mitochondrial dynamics as an integral modulator of MuSC activity, fate, and maintenance. Understanding the influence of mitochondrial dynamics in MuSCs in health and disease will further the development of therapeutics that support MuSC integrity and thus may aid in restoring the regenerative capacity of skeletal muscle.https://www.mdpi.com/2073-4409/13/21/1773mitochondriamitochondrial dynamicsmuscle stem cellsOPA1DRP1reactive oxygen species (ROS) |
| spellingShingle | Olivia Sommers Rholls A. Tomsine Mireille Khacho Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation Cells mitochondria mitochondrial dynamics muscle stem cells OPA1 DRP1 reactive oxygen species (ROS) |
| title | Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation |
| title_full | Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation |
| title_fullStr | Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation |
| title_full_unstemmed | Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation |
| title_short | Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation |
| title_sort | mitochondrial dynamics drive muscle stem cell progression from quiescence to myogenic differentiation |
| topic | mitochondria mitochondrial dynamics muscle stem cells OPA1 DRP1 reactive oxygen species (ROS) |
| url | https://www.mdpi.com/2073-4409/13/21/1773 |
| work_keys_str_mv | AT oliviasommers mitochondrialdynamicsdrivemusclestemcellprogressionfromquiescencetomyogenicdifferentiation AT rhollsatomsine mitochondrialdynamicsdrivemusclestemcellprogressionfromquiescencetomyogenicdifferentiation AT mireillekhacho mitochondrialdynamicsdrivemusclestemcellprogressionfromquiescencetomyogenicdifferentiation |