Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences

Smoking increases the risk of peptic ulcer disease and death from it. Smoking delays peptic ulcer healing, with or without treatment, and increases the risk of recurrence after healing. Th...

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Main Author: Mary Jane Ashley
Format: Article
Language:English
Published: Wiley 1997-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1997/539451
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author Mary Jane Ashley
author_facet Mary Jane Ashley
author_sort Mary Jane Ashley
collection DOAJ
description Smoking increases the risk of peptic ulcer disease and death from it. Smoking delays peptic ulcer healing, with or without treatment, and increases the risk of recurrence after healing. The effects of smoking on this disease are similar and equally pervasive in women and men. There is growing evidence that cigarette smoking is a risk factor for Crohn's disease (CD) in both women and men. However, women smokers appear to be at particular risk for this disease. In studies that examined this risk separately in women and men, at each level of smoking the excess risk in women smokers compared with nonsmokers clearly exceeded the excess risk in men smokers compared with nonsmokers. Smoking also appears to adversely affect the clinical course of CD in both women and men, but more so in women. The possible interaction between smoking and oral contraceptives with regard to the risk of CD deserves further study. There is growing evidence that current smoking protects against ulcerative colitis in both men and women. Although there is some evidence that smoking is a risk factor for gallstones, particularly in women, evidence to support a causal relationship is inadequate. Further studies, controlling for alcohol consumption in the analyses, are needed. Smoking does not appear to be a risk factor for cirrhosis of the liver.
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spelling doaj-art-faf46508747e4508b464cc87a60d13932025-02-03T00:59:45ZengWileyCanadian Journal of Gastroenterology0835-79001997-01-0111434535210.1155/1997/539451Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex DifferencesMary Jane AshleySmoking increases the risk of peptic ulcer disease and death from it. Smoking delays peptic ulcer healing, with or without treatment, and increases the risk of recurrence after healing. The effects of smoking on this disease are similar and equally pervasive in women and men. There is growing evidence that cigarette smoking is a risk factor for Crohn's disease (CD) in both women and men. However, women smokers appear to be at particular risk for this disease. In studies that examined this risk separately in women and men, at each level of smoking the excess risk in women smokers compared with nonsmokers clearly exceeded the excess risk in men smokers compared with nonsmokers. Smoking also appears to adversely affect the clinical course of CD in both women and men, but more so in women. The possible interaction between smoking and oral contraceptives with regard to the risk of CD deserves further study. There is growing evidence that current smoking protects against ulcerative colitis in both men and women. Although there is some evidence that smoking is a risk factor for gallstones, particularly in women, evidence to support a causal relationship is inadequate. Further studies, controlling for alcohol consumption in the analyses, are needed. Smoking does not appear to be a risk factor for cirrhosis of the liver.http://dx.doi.org/10.1155/1997/539451
spellingShingle Mary Jane Ashley
Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences
Canadian Journal of Gastroenterology
title Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences
title_full Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences
title_fullStr Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences
title_full_unstemmed Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences
title_short Smoking and Diseases of the Gastrointestinal System: An Epidemiological Review with Special Reference to Sex Differences
title_sort smoking and diseases of the gastrointestinal system an epidemiological review with special reference to sex differences
url http://dx.doi.org/10.1155/1997/539451
work_keys_str_mv AT maryjaneashley smokinganddiseasesofthegastrointestinalsystemanepidemiologicalreviewwithspecialreferencetosexdifferences