Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018
Background: This study aimed to develop and validate a predictive model for major depression risk in adult patients with coronary heart disease (CHD), offering evidence for targeted prevention and intervention. Methods:...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25998 |
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| author | Li-xiang Zhang Shan-bing Hou Fang-fang Zhao Ting-ting Wang Ying Jiang Xiao-juan Zhou Jiao-yu Cao |
| author_facet | Li-xiang Zhang Shan-bing Hou Fang-fang Zhao Ting-ting Wang Ying Jiang Xiao-juan Zhou Jiao-yu Cao |
| author_sort | Li-xiang Zhang |
| collection | DOAJ |
| description | Background: This study aimed to develop and validate a predictive model for major depression risk in adult patients with coronary heart disease (CHD), offering evidence for targeted prevention and intervention. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 1098 adults with CHD were included. A weighted logistic regression model was applied to construct and validate a nomogram-based prediction tool for major depression in this population. Results: The weighted prevalence of major depression among these patients was 13.95%. Multivariate weighted logistic regression revealed that waist circumference, smoking status, arthritis, sleep disorders, and restricted work capacity were independent risk factors for major depression (odds ratio (OR) >1, p < 0.05). The areas under the receiver operating characteristic (ROC) curve in the nomogram model for both the development and validation cohorts were 0.816 (95% confidence interval (CI): 0.776–0.857) and 0.765 (95% CI: 0.699–0.832), respectively, indicating the model possessed strong discriminative ability. Brier scores in the development and validation cohorts were 0.107 and 0.127, respectively, both well below the 0.25 threshold, demonstrating good calibration. Decision curve analysis (DCA) showed that when the threshold probability for major depression ranged from 0.04 to 0.54 in the development group and from 0.08 to 0.52 in the validation group, the nomogram provided the highest clinical net benefit compared to “Treat All” and “Treat None” strategies, confirming its strong clinical utility. Conclusions: With a weighted prevalence of 13.95%, this nomogram model shows excellent predictive performance and clinical relevance for predicting major depression risk in patients with CHD. Thus, the model can be applied to aid healthcare professionals in identifying high-risk individuals and implementing targeted preventive strategies, potentially lowering the incidence of major depression in this patient population. |
| format | Article |
| id | doaj-art-faeb39f811364bd8818d1313be6d64c5 |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-faeb39f811364bd8818d1313be6d64c52025-01-25T10:41:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612599810.31083/RCM25998S1530-6550(24)01628-4Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018Li-xiang Zhang0Shan-bing Hou1Fang-fang Zhao2Ting-ting Wang3Ying Jiang4Xiao-juan Zhou5Jiao-yu Cao6Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaDepartment of Emergency, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaDepartment of Emergency, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaBackground: This study aimed to develop and validate a predictive model for major depression risk in adult patients with coronary heart disease (CHD), offering evidence for targeted prevention and intervention. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 1098 adults with CHD were included. A weighted logistic regression model was applied to construct and validate a nomogram-based prediction tool for major depression in this population. Results: The weighted prevalence of major depression among these patients was 13.95%. Multivariate weighted logistic regression revealed that waist circumference, smoking status, arthritis, sleep disorders, and restricted work capacity were independent risk factors for major depression (odds ratio (OR) >1, p < 0.05). The areas under the receiver operating characteristic (ROC) curve in the nomogram model for both the development and validation cohorts were 0.816 (95% confidence interval (CI): 0.776–0.857) and 0.765 (95% CI: 0.699–0.832), respectively, indicating the model possessed strong discriminative ability. Brier scores in the development and validation cohorts were 0.107 and 0.127, respectively, both well below the 0.25 threshold, demonstrating good calibration. Decision curve analysis (DCA) showed that when the threshold probability for major depression ranged from 0.04 to 0.54 in the development group and from 0.08 to 0.52 in the validation group, the nomogram provided the highest clinical net benefit compared to “Treat All” and “Treat None” strategies, confirming its strong clinical utility. Conclusions: With a weighted prevalence of 13.95%, this nomogram model shows excellent predictive performance and clinical relevance for predicting major depression risk in patients with CHD. Thus, the model can be applied to aid healthcare professionals in identifying high-risk individuals and implementing targeted preventive strategies, potentially lowering the incidence of major depression in this patient population.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25998coronary heart diseasemajor depressionnhanesrisk factorspredictive model |
| spellingShingle | Li-xiang Zhang Shan-bing Hou Fang-fang Zhao Ting-ting Wang Ying Jiang Xiao-juan Zhou Jiao-yu Cao Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018 Reviews in Cardiovascular Medicine coronary heart disease major depression nhanes risk factors predictive model |
| title | Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018 |
| title_full | Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018 |
| title_fullStr | Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018 |
| title_full_unstemmed | Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018 |
| title_short | Construction and Validation of a Major Depression Risk Predictive Model for Patients with Coronary Heart Disease: Insights from NHANES 2005–2018 |
| title_sort | construction and validation of a major depression risk predictive model for patients with coronary heart disease insights from nhanes 2005 2018 |
| topic | coronary heart disease major depression nhanes risk factors predictive model |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25998 |
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