Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese
Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and viscer...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1567467 |
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| author | Chikako Fujii Toshihide Kawai Koichiro Azuma Yuko Oguma Fuminori Katsukawa Hiroshi Hirose Kumiko Tanaka Shu Meguro Hideo Matsumoto Hiroshi Itoh |
| author_facet | Chikako Fujii Toshihide Kawai Koichiro Azuma Yuko Oguma Fuminori Katsukawa Hiroshi Hirose Kumiko Tanaka Shu Meguro Hideo Matsumoto Hiroshi Itoh |
| author_sort | Chikako Fujii |
| collection | DOAJ |
| description | Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r=−0.411, p<0.0001), fasting glucose (r=−0.330, p<0.0001), HbA1c (r=−0.231, p=0.0146), and systolic blood pressure (r=−0.224, p=0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r=−0.416, p<0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. Conclusion. We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects. |
| format | Article |
| id | doaj-art-fae260f9693c48f695f7c7123902e20d |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fae260f9693c48f695f7c7123902e20d2025-02-03T06:06:15ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/15674671567467Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in JapaneseChikako Fujii0Toshihide Kawai1Koichiro Azuma2Yuko Oguma3Fuminori Katsukawa4Hiroshi Hirose5Kumiko Tanaka6Shu Meguro7Hideo Matsumoto8Hiroshi Itoh9Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Keio University School of Medicine, Tokyo, JapanInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Keio University School of Medicine, Tokyo, JapanInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Keio University School of Medicine, Tokyo, JapanObjective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r=−0.411, p<0.0001), fasting glucose (r=−0.330, p<0.0001), HbA1c (r=−0.231, p=0.0146), and systolic blood pressure (r=−0.224, p=0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r=−0.416, p<0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. Conclusion. We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.http://dx.doi.org/10.1155/2017/1567467 |
| spellingShingle | Chikako Fujii Toshihide Kawai Koichiro Azuma Yuko Oguma Fuminori Katsukawa Hiroshi Hirose Kumiko Tanaka Shu Meguro Hideo Matsumoto Hiroshi Itoh Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese Journal of Diabetes Research |
| title | Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese |
| title_full | Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese |
| title_fullStr | Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese |
| title_full_unstemmed | Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese |
| title_short | Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese |
| title_sort | relationships between composition of major fatty acids and fat distribution and insulin resistance in japanese |
| url | http://dx.doi.org/10.1155/2017/1567467 |
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