Injectable iodine-containing peptide hydrogel for treatment of MRSA infection
Iodine is widely acknowledged for its potent antimicrobial properties. However, its clinical utility is often hampered by its unsatisfactory stability, uncontrolled release of active iodine and toxicity in moist environments. In this study, we report a novel iodine-containing hydrogel (I2@Nap-FFGP)...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25000106 |
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| author | Yu Zhang Haiyan Liu Weiqi Zhang Yinghao Ding Shengyi Zhang Xiaowan Huang Jiali Chen Zhimou Yang Feng Lin |
| author_facet | Yu Zhang Haiyan Liu Weiqi Zhang Yinghao Ding Shengyi Zhang Xiaowan Huang Jiali Chen Zhimou Yang Feng Lin |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Iodine is widely acknowledged for its potent antimicrobial properties. However, its clinical utility is often hampered by its unsatisfactory stability, uncontrolled release of active iodine and toxicity in moist environments. In this study, we report a novel iodine-containing hydrogel (I2@Nap-FFGP) designed for sustained iodine delivery under humid physiological and pathological conditions. I2@Nap-FFGP was fabricated using a self-assembling peptide-based hydrogel containing a proline motif to form a stable iodine complex. The resulting hydrogel exhibited excellent biocompatibility and robust antibacterial effect, it significantly inhibited bacteria-associated endometrial infections in mice and effectively alleviated inflammation. Moreover, the hydrogel successfully restored endometrial architecture and function. Notably, I2@Nap-FFGP remarkably improved pregnancy rates in mice with endometritis owing to its therapeutic effects. Our findings highlight the potential of this innovative hydrogel system for stable iodine application under humid and aqueous physiological conditions, offering a promising platform for future antibacterial therapies in clinical settings. |
| format | Article |
| id | doaj-art-fad92fe3a009498a8741790539e0b206 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-fad92fe3a009498a8741790539e0b2062025-01-24T04:45:32ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-05-0147198208Injectable iodine-containing peptide hydrogel for treatment of MRSA infectionYu Zhang0Haiyan Liu1Weiqi Zhang2Yinghao Ding3Shengyi Zhang4Xiaowan Huang5Jiali Chen6Zhimou Yang7Feng Lin8Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, PR ChinaDepartment of Gynecology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR ChinaDepartment of Gynecology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR ChinaState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, PR ChinaState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, PR ChinaDepartment of Gynecology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR ChinaZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; Corresponding author.Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, PR China; Corresponding author. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China.Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; Corresponding author.Iodine is widely acknowledged for its potent antimicrobial properties. However, its clinical utility is often hampered by its unsatisfactory stability, uncontrolled release of active iodine and toxicity in moist environments. In this study, we report a novel iodine-containing hydrogel (I2@Nap-FFGP) designed for sustained iodine delivery under humid physiological and pathological conditions. I2@Nap-FFGP was fabricated using a self-assembling peptide-based hydrogel containing a proline motif to form a stable iodine complex. The resulting hydrogel exhibited excellent biocompatibility and robust antibacterial effect, it significantly inhibited bacteria-associated endometrial infections in mice and effectively alleviated inflammation. Moreover, the hydrogel successfully restored endometrial architecture and function. Notably, I2@Nap-FFGP remarkably improved pregnancy rates in mice with endometritis owing to its therapeutic effects. Our findings highlight the potential of this innovative hydrogel system for stable iodine application under humid and aqueous physiological conditions, offering a promising platform for future antibacterial therapies in clinical settings.http://www.sciencedirect.com/science/article/pii/S2452199X25000106IodinePeptideSelf-assemblyAntibacterialEndometritis |
| spellingShingle | Yu Zhang Haiyan Liu Weiqi Zhang Yinghao Ding Shengyi Zhang Xiaowan Huang Jiali Chen Zhimou Yang Feng Lin Injectable iodine-containing peptide hydrogel for treatment of MRSA infection Bioactive Materials Iodine Peptide Self-assembly Antibacterial Endometritis |
| title | Injectable iodine-containing peptide hydrogel for treatment of MRSA infection |
| title_full | Injectable iodine-containing peptide hydrogel for treatment of MRSA infection |
| title_fullStr | Injectable iodine-containing peptide hydrogel for treatment of MRSA infection |
| title_full_unstemmed | Injectable iodine-containing peptide hydrogel for treatment of MRSA infection |
| title_short | Injectable iodine-containing peptide hydrogel for treatment of MRSA infection |
| title_sort | injectable iodine containing peptide hydrogel for treatment of mrsa infection |
| topic | Iodine Peptide Self-assembly Antibacterial Endometritis |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25000106 |
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