Neonatal Sepsis and Inflammatory Mediators
Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics....
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/269681 |
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| author | Juliana Reis Machado Danilo Figueiredo Soave Marcos Vinícius da Silva Liliana Borges de Menezes Renata Margarida Etchebehere Maria Luiza Gonçalves dos Reis Monteiro Marlene Antônia dos Reis Rosana Rosa Miranda Corrêa Mara Rúbia Nunes Celes |
| author_facet | Juliana Reis Machado Danilo Figueiredo Soave Marcos Vinícius da Silva Liliana Borges de Menezes Renata Margarida Etchebehere Maria Luiza Gonçalves dos Reis Monteiro Marlene Antônia dos Reis Rosana Rosa Miranda Corrêa Mara Rúbia Nunes Celes |
| author_sort | Juliana Reis Machado |
| collection | DOAJ |
| description | Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion. |
| format | Article |
| id | doaj-art-facdb43afea6473ea5bf7d9585a9fe0d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-facdb43afea6473ea5bf7d9585a9fe0d2025-02-03T01:21:54ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/269681269681Neonatal Sepsis and Inflammatory MediatorsJuliana Reis Machado0Danilo Figueiredo Soave1Marcos Vinícius da Silva2Liliana Borges de Menezes3Renata Margarida Etchebehere4Maria Luiza Gonçalves dos Reis Monteiro5Marlene Antônia dos Reis6Rosana Rosa Miranda Corrêa7Mara Rúbia Nunes Celes8Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goias, 74605-050 Goiania, GO, BrazilDepartment of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049-900 Ribeirao Preto, SP, BrazilLaboratory of Immunology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, 38025-180 Uberaba, MG, BrazilDepartment of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goias, 74605-050 Goiania, GO, BrazilSurgical Pathology Service, Clinical Hospital, Federal University of Triangulo Mineiro, 38025-180 Uberaba, MG, BrazilDepartment of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, 74605-050 Uberaba, MG, BrazilDepartment of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, 74605-050 Uberaba, MG, BrazilDepartment of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, 74605-050 Uberaba, MG, BrazilDepartment of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goias, 74605-050 Goiania, GO, BrazilNeonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.http://dx.doi.org/10.1155/2014/269681 |
| spellingShingle | Juliana Reis Machado Danilo Figueiredo Soave Marcos Vinícius da Silva Liliana Borges de Menezes Renata Margarida Etchebehere Maria Luiza Gonçalves dos Reis Monteiro Marlene Antônia dos Reis Rosana Rosa Miranda Corrêa Mara Rúbia Nunes Celes Neonatal Sepsis and Inflammatory Mediators Mediators of Inflammation |
| title | Neonatal Sepsis and Inflammatory Mediators |
| title_full | Neonatal Sepsis and Inflammatory Mediators |
| title_fullStr | Neonatal Sepsis and Inflammatory Mediators |
| title_full_unstemmed | Neonatal Sepsis and Inflammatory Mediators |
| title_short | Neonatal Sepsis and Inflammatory Mediators |
| title_sort | neonatal sepsis and inflammatory mediators |
| url | http://dx.doi.org/10.1155/2014/269681 |
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