Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology
Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation and progression of varied disorders throughout the body. It therefore becomes imperative to elucidate the components and function of novel therapeutic strategies against oxidative stress to further clin...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.121 |
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| _version_ | 1832568330225975296 |
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| author | Kenneth Maiese Jinling Hou Zhao Zhong Chong Yan Chen Shang |
| author_facet | Kenneth Maiese Jinling Hou Zhao Zhong Chong Yan Chen Shang |
| author_sort | Kenneth Maiese |
| collection | DOAJ |
| description | Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation and progression of varied disorders throughout the body. It therefore becomes imperative to elucidate the components and function of novel therapeutic strategies against oxidative stress to further clinical diagnosis and care. In particular, both the growth factor and cytokine erythropoietin (EPO), and members of the mammalian forkhead transcription factors of the O class (FoxOs), may offer the greatest promise for new treatment regimens, since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. Furthermore, both EPO and FoxOs function not only as therapeutic targets, but also as biomarkers of disease onset and progression, since their cellular pathways are closely linked and overlap with several unique signal transduction pathways. Yet, EPO and FoxOs may sometimes have unexpected and undesirable effects that can raise caution for these agents and warrant further investigations. Here we present the exciting as well as the complex role that EPO and FoxOs possess to uncover the benefits as well as the risks of these agents for cell biology and clinical care in processes that range from stem cell development to uncontrolled cellular proliferation. |
| format | Article |
| id | doaj-art-fac38d753c4b489bb29659a4c96c8728 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fac38d753c4b489bb29659a4c96c87282025-02-03T00:59:19ZengWileyThe Scientific World Journal1537-744X2009-01-0191072110410.1100/tsw.2009.121Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and BiologyKenneth Maiese0Jinling Hou1Zhao Zhong Chong2Yan Chen Shang3Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI, USACenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USACenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USACenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USAOxidative stress significantly impacts multiple cellular pathways that can lead to the initiation and progression of varied disorders throughout the body. It therefore becomes imperative to elucidate the components and function of novel therapeutic strategies against oxidative stress to further clinical diagnosis and care. In particular, both the growth factor and cytokine erythropoietin (EPO), and members of the mammalian forkhead transcription factors of the O class (FoxOs), may offer the greatest promise for new treatment regimens, since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. Furthermore, both EPO and FoxOs function not only as therapeutic targets, but also as biomarkers of disease onset and progression, since their cellular pathways are closely linked and overlap with several unique signal transduction pathways. Yet, EPO and FoxOs may sometimes have unexpected and undesirable effects that can raise caution for these agents and warrant further investigations. Here we present the exciting as well as the complex role that EPO and FoxOs possess to uncover the benefits as well as the risks of these agents for cell biology and clinical care in processes that range from stem cell development to uncontrolled cellular proliferation.http://dx.doi.org/10.1100/tsw.2009.121 |
| spellingShingle | Kenneth Maiese Jinling Hou Zhao Zhong Chong Yan Chen Shang Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology The Scientific World Journal |
| title | Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology |
| title_full | Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology |
| title_fullStr | Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology |
| title_full_unstemmed | Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology |
| title_short | Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology |
| title_sort | erythropoietin forkhead proteins and oxidative injury biomarkers and biology |
| url | http://dx.doi.org/10.1100/tsw.2009.121 |
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