Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas
Transferrin Receptor 2 (TfR2) is a homolog of Transferrin Receptor 1 (TfR1), involved in regulating intra and extracellular iron levels. Altered iron pathways have been associated with cancer onset and progression; however, their role in canine tumors remains poorly explored. This study investigated...
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MDPI AG
2025-01-01
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| author | Rebecca Leandri Sara Buonocore Karen Power |
| author_facet | Rebecca Leandri Sara Buonocore Karen Power |
| author_sort | Rebecca Leandri |
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| description | Transferrin Receptor 2 (TfR2) is a homolog of Transferrin Receptor 1 (TfR1), involved in regulating intra and extracellular iron levels. Altered iron pathways have been associated with cancer onset and progression; however, their role in canine tumors remains poorly explored. This study investigated TfR2 immunohistochemical expression in non-neoplastic canine testis for the first time and in the most common types of canine testicular tumors: intratubular seminomas (ITSEMs), diffuse seminomas (DSEMs), Leydig cell tumors (LCTs), and Sertoli cell tumors (SCTs). Immunohistochemical analysis revealed a differential pattern of TfR2 expression according to tumor type, with high expression observed in ITSEMs and DSEMs, occasional expression in LCTs, and absence in SCTs. These results suggest that TfR2 may play a relevant role in canine seminoma development. Furthermore, the specific expression of TfR2 in seminomas highlights its potential as a therapeutic target, where its role in iron regulation and possible compensatory mechanisms warrant further investigation. |
| format | Article |
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| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-fabf6b9257164f0a9d679c057e3831ae2025-01-24T13:18:20ZengMDPI AGAnimals2076-26152025-01-0115226410.3390/ani15020264Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in SeminomasRebecca Leandri0Sara Buonocore1Karen Power2Department of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyTransferrin Receptor 2 (TfR2) is a homolog of Transferrin Receptor 1 (TfR1), involved in regulating intra and extracellular iron levels. Altered iron pathways have been associated with cancer onset and progression; however, their role in canine tumors remains poorly explored. This study investigated TfR2 immunohistochemical expression in non-neoplastic canine testis for the first time and in the most common types of canine testicular tumors: intratubular seminomas (ITSEMs), diffuse seminomas (DSEMs), Leydig cell tumors (LCTs), and Sertoli cell tumors (SCTs). Immunohistochemical analysis revealed a differential pattern of TfR2 expression according to tumor type, with high expression observed in ITSEMs and DSEMs, occasional expression in LCTs, and absence in SCTs. These results suggest that TfR2 may play a relevant role in canine seminoma development. Furthermore, the specific expression of TfR2 in seminomas highlights its potential as a therapeutic target, where its role in iron regulation and possible compensatory mechanisms warrant further investigation.https://www.mdpi.com/2076-2615/15/2/264canine testicular tumorimmunohistochemistryironTfR2seminomatherapy |
| spellingShingle | Rebecca Leandri Sara Buonocore Karen Power Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas Animals canine testicular tumor immunohistochemistry iron TfR2 seminoma therapy |
| title | Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas |
| title_full | Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas |
| title_fullStr | Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas |
| title_full_unstemmed | Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas |
| title_short | Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas |
| title_sort | transferrin receptor 2 in canine testicular tumors an emerging key role in seminomas |
| topic | canine testicular tumor immunohistochemistry iron TfR2 seminoma therapy |
| url | https://www.mdpi.com/2076-2615/15/2/264 |
| work_keys_str_mv | AT rebeccaleandri transferrinreceptor2incaninetesticulartumorsanemergingkeyroleinseminomas AT sarabuonocore transferrinreceptor2incaninetesticulartumorsanemergingkeyroleinseminomas AT karenpower transferrinreceptor2incaninetesticulartumorsanemergingkeyroleinseminomas |