Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients
Nanoindentation allows quantitative determination of a material’s response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-09-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2016-0032 |
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| _version_ | 1832571488209731584 |
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| author | Egart Mateja Janković Biljana Srčič Stane |
| author_facet | Egart Mateja Janković Biljana Srčič Stane |
| author_sort | Egart Mateja |
| collection | DOAJ |
| description | Nanoindentation allows quantitative determination of a material’s response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision. |
| format | Article |
| id | doaj-art-fab4c2932d4740e59fe2520dd53fea17 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-fab4c2932d4740e59fe2520dd53fea172025-02-02T12:35:44ZengSciendoActa Pharmaceutica1846-95582016-09-0166330333010.1515/acph-2016-0032acph-2016-0032Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipientsEgart Mateja0Janković Biljana1Srčič Stane2Faculty of Pharmacy University of Ljubljana 1000 Ljubljana, SloveniaFaculty of Pharmacy University of Ljubljana 1000 Ljubljana, SloveniaFaculty of Pharmacy University of Ljubljana 1000 Ljubljana, SloveniaNanoindentation allows quantitative determination of a material’s response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision.https://doi.org/10.1515/acph-2016-0032instrumented nanoindentationmechanical propertiesyoung’s modulusindentation hardnessfracture toughnesscrystalline active ingredients and excipients |
| spellingShingle | Egart Mateja Janković Biljana Srčič Stane Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients Acta Pharmaceutica instrumented nanoindentation mechanical properties young’s modulus indentation hardness fracture toughness crystalline active ingredients and excipients |
| title | Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients |
| title_full | Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients |
| title_fullStr | Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients |
| title_full_unstemmed | Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients |
| title_short | Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients |
| title_sort | application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients |
| topic | instrumented nanoindentation mechanical properties young’s modulus indentation hardness fracture toughness crystalline active ingredients and excipients |
| url | https://doi.org/10.1515/acph-2016-0032 |
| work_keys_str_mv | AT egartmateja applicationofinstrumentednanoindentationinpreformulationstudiesofpharmaceuticalactiveingredientsandexcipients AT jankovicbiljana applicationofinstrumentednanoindentationinpreformulationstudiesofpharmaceuticalactiveingredientsandexcipients AT srcicstane applicationofinstrumentednanoindentationinpreformulationstudiesofpharmaceuticalactiveingredientsandexcipients |