Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults
BackgroundResearch indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, the relationship between GHR and the risk of gallbladder stones remains unclear. This study investigates the poss...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1528613/full |
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| author | Bo Wu Huachao Zheng Caixiang Zhuang Jiesheng Mao Luo Yuncheng Lidong Huang Min Li Zhao Feiyang Sisi Lin Pengwei Wang Yiren Hu |
| author_facet | Bo Wu Huachao Zheng Caixiang Zhuang Jiesheng Mao Luo Yuncheng Lidong Huang Min Li Zhao Feiyang Sisi Lin Pengwei Wang Yiren Hu |
| author_sort | Bo Wu |
| collection | DOAJ |
| description | BackgroundResearch indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, the relationship between GHR and the risk of gallbladder stones remains unclear. This study investigates the possible relationship between GHR and the incidence of gallbladder stones.MethodsThis research used information gathered from the National Health and Nutrition Examination Survey (NHANES) between March 2017 and March 2020. A calculation was made to determine the GHR by dividing the fasting blood glucose level by the HDL-C level. Several statistical methods, including analysis of threshold effects, smoothed curve fitting, multiple logistic regression modeling, and subgroup analysis, were utilized to investigate the connection between GHR and gallstones.ResultsIn 3898 U.S. adults, GHR was significantly positively associated with the prevalence of gallbladder stones. In a fully adjusted model, the incidence of gallbladder stones increased by 7% with each 1-unit increase in GHR (OR [95% Cl] = 1.07 [1.02, 1.14]). Compared with members in the low group, those in the high group had a 100% higher likelihood of getting gallbladder stones (OR [95% CI] = 2.00 [1.31, 3.04]), and this stabilizing connection was always present in the different subgroups. With the help of smooth curve fitting, the research also showed that there was a connection that was formed like an upside-down L shape between GHR and gallbladder stones. The analysis of the threshold effect revealed that the inflection point was 4.28.ConclusionThe results revealed an inverted L-shaped connection between GHR and gallbladder stones. Keeping GHR levels within a certain range is associated with a lower incidence of gallstones in the general population. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-fab1c0bc33a34d80bcca688faa7c92c82025-01-30T06:22:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15286131528613Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adultsBo Wu0Huachao Zheng1Caixiang Zhuang2Jiesheng Mao3Luo Yuncheng4Lidong Huang5Min Li6Zhao Feiyang7Sisi Lin8Pengwei Wang9Yiren Hu10Department of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of Neurology, The Third Clinical Medical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of Neurology, The Third Clinical Medical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University (Wenzhou People’s Hospital), Wenzhou, ChinaBackgroundResearch indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, the relationship between GHR and the risk of gallbladder stones remains unclear. This study investigates the possible relationship between GHR and the incidence of gallbladder stones.MethodsThis research used information gathered from the National Health and Nutrition Examination Survey (NHANES) between March 2017 and March 2020. A calculation was made to determine the GHR by dividing the fasting blood glucose level by the HDL-C level. Several statistical methods, including analysis of threshold effects, smoothed curve fitting, multiple logistic regression modeling, and subgroup analysis, were utilized to investigate the connection between GHR and gallstones.ResultsIn 3898 U.S. adults, GHR was significantly positively associated with the prevalence of gallbladder stones. In a fully adjusted model, the incidence of gallbladder stones increased by 7% with each 1-unit increase in GHR (OR [95% Cl] = 1.07 [1.02, 1.14]). Compared with members in the low group, those in the high group had a 100% higher likelihood of getting gallbladder stones (OR [95% CI] = 2.00 [1.31, 3.04]), and this stabilizing connection was always present in the different subgroups. With the help of smooth curve fitting, the research also showed that there was a connection that was formed like an upside-down L shape between GHR and gallbladder stones. The analysis of the threshold effect revealed that the inflection point was 4.28.ConclusionThe results revealed an inverted L-shaped connection between GHR and gallbladder stones. Keeping GHR levels within a certain range is associated with a lower incidence of gallstones in the general population.https://www.frontiersin.org/articles/10.3389/fmed.2025.1528613/fullgallstonesfasting blood glucosehigh-density lipoprotein cholesterolNHANESdiabetes |
| spellingShingle | Bo Wu Huachao Zheng Caixiang Zhuang Jiesheng Mao Luo Yuncheng Lidong Huang Min Li Zhao Feiyang Sisi Lin Pengwei Wang Yiren Hu Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults Frontiers in Medicine gallstones fasting blood glucose high-density lipoprotein cholesterol NHANES diabetes |
| title | Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults |
| title_full | Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults |
| title_fullStr | Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults |
| title_full_unstemmed | Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults |
| title_short | Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults |
| title_sort | correlation between gallstones and fasting blood glucose to serum high density lipoprotein cholesterol ratio among american adults |
| topic | gallstones fasting blood glucose high-density lipoprotein cholesterol NHANES diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1528613/full |
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