C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia
Background. The relationship between C-reactive protein (CRP) elevation and ventricular tachycardia (VT) in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is unclear. Methods and Results. In 91 consecutive patients with either ARVD/C with or without VT (cases) or idiopathic right...
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Wiley
2010-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2010/919783 |
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| author | Aimé Bonny Nicolas Lellouche Ivo Ditah Françoise Hidden-Lucet Martial T. Yitemben Benjamin Granger Fabrice Larrazet Robert Frank Guy Fontaine |
| author_facet | Aimé Bonny Nicolas Lellouche Ivo Ditah Françoise Hidden-Lucet Martial T. Yitemben Benjamin Granger Fabrice Larrazet Robert Frank Guy Fontaine |
| author_sort | Aimé Bonny |
| collection | DOAJ |
| description | Background. The relationship between C-reactive protein (CRP) elevation and ventricular tachycardia (VT) in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is unclear. Methods and Results. In 91 consecutive patients with either ARVD/C with or without VT (cases) or idiopathic right ventricular outflow tract (RVOT) tachycardia (controls), blood sampling were taken to determine CRP levels. In ARVD/C patients with VT, we analyzed the association between VT occurrences and CRP level. Sixty patients had ARVD/C, and 31 had idiopathic RVOT VT. Patients with ARVD/C had a significant higher level of CRP compared to those with RVOT VT (3.5±4.9 versus 1.1±1.2 mg/l, P=.0004). In ARVD/C group, 77%, (n=46) patients experienced VT. Of these, 37% (n=17) underwent blood testing for CRP within 24 h after the onset of VT and the remaining 63% (n=29) after 24 h of VT reduction. CRP level was similar in ARVD/C patients with or without documented VT (3.6±5.1 mg/l versus 3.1±4.1 mg/l, P=.372). However, in patients with ARVD/C and documented VT, CRP was significantly higher when measured within 24 hours following VT in comparison to that level when measured after 24 h (4.9±6.2 mg/l versus 3.0±4.4 mg/l, P=.049). Conclusion. Inflammatory state is an active process in patients with ARVD/C. Moreover, there is a higher level of CRP in patients soon after ventricular tachycardia, and this probably tends to decrease after the event. |
| format | Article |
| id | doaj-art-fab0df4c0b5848369711b9266222b0c6 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-fab0df4c0b5848369711b9266222b0c62025-02-03T06:13:16ZengWileyCardiology Research and Practice2090-05972010-01-01201010.4061/2010/919783919783C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular TachycardiaAimé Bonny0Nicolas Lellouche1Ivo Ditah2Françoise Hidden-Lucet3Martial T. Yitemben4Benjamin Granger5Fabrice Larrazet6Robert Frank7Guy Fontaine8Service de Cardiologie, Hôpital Saint Camille, 2 rue des pères camilliens, 94366 Bry-sur-Marne, FranceHôpital Henri-Mondor, Fédération de Cardiologie, 51, av Mal de Lattre de Tassigny, 94010 Créteil, FranceDepartment of Internal Medicine, Wayne State University, 5475 Woodward Avenue, Detroit, MI 48202, USAUnité de Rythmologie, Hôpital Pitié Salpêtrière, 47-83, Boulevard de l’Hôpital, 75651 Paris, Cedex 13, FranceService de Médecine, Centre Hospitalier Le Cateau, 28, Boulevard Paturle, 59360 Le Cateau- Cambresis, FranceDépartement de Biostatistique, Hôpital Pitié Salpêtrière, 47-83, Boulevard de l’Hôpital, 75651 Paris, Cedex 13, FranceService de Cardiologie, Hôpital Saint Camille, 2 rue des pères camilliens, 94366 Bry-sur-Marne, FranceUnité de Rythmologie, Hôpital Pitié Salpêtrière, 47-83, Boulevard de l’Hôpital, 75651 Paris, Cedex 13, FranceUnité de Rythmologie, Hôpital Pitié Salpêtrière, 47-83, Boulevard de l’Hôpital, 75651 Paris, Cedex 13, FranceBackground. The relationship between C-reactive protein (CRP) elevation and ventricular tachycardia (VT) in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is unclear. Methods and Results. In 91 consecutive patients with either ARVD/C with or without VT (cases) or idiopathic right ventricular outflow tract (RVOT) tachycardia (controls), blood sampling were taken to determine CRP levels. In ARVD/C patients with VT, we analyzed the association between VT occurrences and CRP level. Sixty patients had ARVD/C, and 31 had idiopathic RVOT VT. Patients with ARVD/C had a significant higher level of CRP compared to those with RVOT VT (3.5±4.9 versus 1.1±1.2 mg/l, P=.0004). In ARVD/C group, 77%, (n=46) patients experienced VT. Of these, 37% (n=17) underwent blood testing for CRP within 24 h after the onset of VT and the remaining 63% (n=29) after 24 h of VT reduction. CRP level was similar in ARVD/C patients with or without documented VT (3.6±5.1 mg/l versus 3.1±4.1 mg/l, P=.372). However, in patients with ARVD/C and documented VT, CRP was significantly higher when measured within 24 hours following VT in comparison to that level when measured after 24 h (4.9±6.2 mg/l versus 3.0±4.4 mg/l, P=.049). Conclusion. Inflammatory state is an active process in patients with ARVD/C. Moreover, there is a higher level of CRP in patients soon after ventricular tachycardia, and this probably tends to decrease after the event.http://dx.doi.org/10.4061/2010/919783 |
| spellingShingle | Aimé Bonny Nicolas Lellouche Ivo Ditah Françoise Hidden-Lucet Martial T. Yitemben Benjamin Granger Fabrice Larrazet Robert Frank Guy Fontaine C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia Cardiology Research and Practice |
| title | C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia |
| title_full | C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia |
| title_fullStr | C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia |
| title_full_unstemmed | C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia |
| title_short | C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia |
| title_sort | c reactive protein in arrhythmogenic right ventricular dysplasia cardiomyopathy and relationship with ventricular tachycardia |
| url | http://dx.doi.org/10.4061/2010/919783 |
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