On the Toxicity of Therapeutically Used Nanoparticles: An Overview
Human beings have been exposed to airborne nanosized particles throughout their evolutionary stages, and such exposures have increased dramatically over the last century. The rapidly developing field of nanotechnology will result in new sources of this exposure, through inhalation, ingestion, and in...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2009/754810 |
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| _version_ | 1832555439023194112 |
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| author | A. El-Ansary S. Al-Daihan |
| author_facet | A. El-Ansary S. Al-Daihan |
| author_sort | A. El-Ansary |
| collection | DOAJ |
| description | Human beings have been exposed to airborne nanosized particles throughout their evolutionary stages, and such exposures have increased dramatically over the last century. The rapidly developing field of nanotechnology will result in new sources of this exposure, through inhalation, ingestion, and injection. Although nanomaterials are currently being widely used in modern technology, there is a serious lack of information concerning the human health and environmental implications of manufactured nanomaterials. Since these are relatively new particles, it is necessary to investigate their toxicological behavior. The objective of this review was to trace the cellular response to nanosized particle exposure. Therapeutic application of selected nanoparticles together with their range of toxic doses was also reviewed. Effect of therapeutically used nanoparticles on cell membrane, mitochondrial function, prooxidant/antioxidant status, enzyme leakage, DNA, and other biochemical endpoints was elucidated. This paper highlights the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts. |
| format | Article |
| id | doaj-art-fab09d784bb5492e80b03ab375cda421 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-fab09d784bb5492e80b03ab375cda4212025-02-03T05:48:18ZengWileyJournal of Toxicology1687-81911687-82052009-01-01200910.1155/2009/754810754810On the Toxicity of Therapeutically Used Nanoparticles: An OverviewA. El-Ansary0S. Al-Daihan1Biochemistry Department, Science College, King Saud University, P.O. Box 22452, Riyadh 11451, Saudi ArabiaBiochemistry Department, Science College, King Saud University, P.O. Box 22452, Riyadh 11451, Saudi ArabiaHuman beings have been exposed to airborne nanosized particles throughout their evolutionary stages, and such exposures have increased dramatically over the last century. The rapidly developing field of nanotechnology will result in new sources of this exposure, through inhalation, ingestion, and injection. Although nanomaterials are currently being widely used in modern technology, there is a serious lack of information concerning the human health and environmental implications of manufactured nanomaterials. Since these are relatively new particles, it is necessary to investigate their toxicological behavior. The objective of this review was to trace the cellular response to nanosized particle exposure. Therapeutic application of selected nanoparticles together with their range of toxic doses was also reviewed. Effect of therapeutically used nanoparticles on cell membrane, mitochondrial function, prooxidant/antioxidant status, enzyme leakage, DNA, and other biochemical endpoints was elucidated. This paper highlights the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts.http://dx.doi.org/10.1155/2009/754810 |
| spellingShingle | A. El-Ansary S. Al-Daihan On the Toxicity of Therapeutically Used Nanoparticles: An Overview Journal of Toxicology |
| title | On the Toxicity of Therapeutically Used Nanoparticles: An Overview |
| title_full | On the Toxicity of Therapeutically Used Nanoparticles: An Overview |
| title_fullStr | On the Toxicity of Therapeutically Used Nanoparticles: An Overview |
| title_full_unstemmed | On the Toxicity of Therapeutically Used Nanoparticles: An Overview |
| title_short | On the Toxicity of Therapeutically Used Nanoparticles: An Overview |
| title_sort | on the toxicity of therapeutically used nanoparticles an overview |
| url | http://dx.doi.org/10.1155/2009/754810 |
| work_keys_str_mv | AT aelansary onthetoxicityoftherapeuticallyusednanoparticlesanoverview AT saldaihan onthetoxicityoftherapeuticallyusednanoparticlesanoverview |