Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease
Objective. Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and a significant cause of morbidity and mortality. The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/406927 |
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| author | Juan Chen YongHong Shi XiaoPing Wang Heqing Huang Dana Ascherman |
| author_facet | Juan Chen YongHong Shi XiaoPing Wang Heqing Huang Dana Ascherman |
| author_sort | Juan Chen |
| collection | DOAJ |
| description | Objective. Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and a significant cause of morbidity and mortality. The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of identifying asymptomatic, preclinical forms of RA-ILD that may represent precursors to more severe fibrotic lung disease. Methods. We analyzed chest HRCTs in consecutively enrolled RA patients and subsequently classified these individuals as RA-ILD or RA-no ILD based on the presence/absence of ground glass opacification, septal thickening, reticulation, traction bronchiectasis, and/or honeycombing. Coexisting PFT abnormalities (reductions in percent predicted FEV1, FVC, TLC, and/or DLCO) were also used to further characterize occult respiratory defects. Results. 61% (63/103) of RA patients were classified as RA-ILD based on HRCT and PFT abnormalities, while 39% (40/103) were designated as RA-no ILD. 57/63 RA-ILD patients lacked symptoms of significant dyspnea or cough at the time of HRCT and PFT assessment. Compared with RA-no ILD, RA-ILD patients were older and had longer disease duration, higher articular disease activity, and more significant PFT abnormalities. Conclusion. HRCT represents an effective tool to detect occult/asymptomatic ILD that is highly prevalent in our unselected, university-based cohort of RA patients. |
| format | Article |
| id | doaj-art-faadb43f297b4e1aa05f654000f3db21 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-faadb43f297b4e1aa05f654000f3db212025-08-20T02:22:37ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/406927406927Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung DiseaseJuan Chen0YongHong Shi1XiaoPing Wang2Heqing Huang3Dana Ascherman4Rheumatology Department of the First Hospital of Xiamen University, Zhen Hai Road No. 55, Xiamen 361003, ChinaPulmonary Department of the First Hospital of Xiamen University, Zhen Hai Road No. 55, Xiamen 361003, ChinaRadiology Department of the First Hospital of Xiamen University, Zhen Hai Road No. 55, Xiamen 361003, ChinaRheumatology Department of the First Hospital of Xiamen University, Zhen Hai Road No. 55, Xiamen 361003, ChinaUniversity of Miami School of Medicine, Miami, FL 33136, USAObjective. Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and a significant cause of morbidity and mortality. The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of identifying asymptomatic, preclinical forms of RA-ILD that may represent precursors to more severe fibrotic lung disease. Methods. We analyzed chest HRCTs in consecutively enrolled RA patients and subsequently classified these individuals as RA-ILD or RA-no ILD based on the presence/absence of ground glass opacification, septal thickening, reticulation, traction bronchiectasis, and/or honeycombing. Coexisting PFT abnormalities (reductions in percent predicted FEV1, FVC, TLC, and/or DLCO) were also used to further characterize occult respiratory defects. Results. 61% (63/103) of RA patients were classified as RA-ILD based on HRCT and PFT abnormalities, while 39% (40/103) were designated as RA-no ILD. 57/63 RA-ILD patients lacked symptoms of significant dyspnea or cough at the time of HRCT and PFT assessment. Compared with RA-no ILD, RA-ILD patients were older and had longer disease duration, higher articular disease activity, and more significant PFT abnormalities. Conclusion. HRCT represents an effective tool to detect occult/asymptomatic ILD that is highly prevalent in our unselected, university-based cohort of RA patients.http://dx.doi.org/10.1155/2013/406927 |
| spellingShingle | Juan Chen YongHong Shi XiaoPing Wang Heqing Huang Dana Ascherman Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease Clinical and Developmental Immunology |
| title | Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_full | Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_fullStr | Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_full_unstemmed | Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_short | Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_sort | asymptomatic preclinical rheumatoid arthritis associated interstitial lung disease |
| url | http://dx.doi.org/10.1155/2013/406927 |
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