Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression
Novel therapeutics used in the treatment of inflammatory bowel disease pose an increased risk of viral reactivation in patients. We present a case of a patient with refractory Crohn’s disease (CD) who developed primary varicella (chickenpox) of a vaccine-viral strain after receiving combination immu...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/crgm/6088333 |
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| author | Quintin Solano Sarah Uttal Peter D. R. Higgins Jeffrey A. Berinstein |
| author_facet | Quintin Solano Sarah Uttal Peter D. R. Higgins Jeffrey A. Berinstein |
| author_sort | Quintin Solano |
| collection | DOAJ |
| description | Novel therapeutics used in the treatment of inflammatory bowel disease pose an increased risk of viral reactivation in patients. We present a case of a patient with refractory Crohn’s disease (CD) who developed primary varicella (chickenpox) of a vaccine-viral strain after receiving combination immunosuppression with high-dose corticosteroids, tumor necrosis factor inhibitor (TNFi), and a Janus kinase inhibitor (JAKi) in the hospital. While this patient recovered and did not experience long term adverse effects, her case provides an opportunity for improvement. To improve safety, healthcare facilities should develop protocols that use electronic medical records enhanced with clinical decision support systems to identify and protect immunocompromised patients from inappropriate live vaccinations. |
| format | Article |
| id | doaj-art-faa9287f7f3c43edadf0deb592ddfc21 |
| institution | Kabale University |
| issn | 2090-6536 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-faa9287f7f3c43edadf0deb592ddfc212025-01-28T05:00:00ZengWileyCase Reports in Gastrointestinal Medicine2090-65362025-01-01202510.1155/crgm/6088333Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination ImmunosuppressionQuintin Solano0Sarah Uttal1Peter D. R. Higgins2Jeffrey A. Berinstein3Department of Internal MedicineDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyNovel therapeutics used in the treatment of inflammatory bowel disease pose an increased risk of viral reactivation in patients. We present a case of a patient with refractory Crohn’s disease (CD) who developed primary varicella (chickenpox) of a vaccine-viral strain after receiving combination immunosuppression with high-dose corticosteroids, tumor necrosis factor inhibitor (TNFi), and a Janus kinase inhibitor (JAKi) in the hospital. While this patient recovered and did not experience long term adverse effects, her case provides an opportunity for improvement. To improve safety, healthcare facilities should develop protocols that use electronic medical records enhanced with clinical decision support systems to identify and protect immunocompromised patients from inappropriate live vaccinations.http://dx.doi.org/10.1155/crgm/6088333 |
| spellingShingle | Quintin Solano Sarah Uttal Peter D. R. Higgins Jeffrey A. Berinstein Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression Case Reports in Gastrointestinal Medicine |
| title | Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression |
| title_full | Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression |
| title_fullStr | Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression |
| title_full_unstemmed | Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression |
| title_short | Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn’s Disease Patient on Combination Immunosuppression |
| title_sort | disseminated chickenpox following live varicella vaccination in a crohn s disease patient on combination immunosuppression |
| url | http://dx.doi.org/10.1155/crgm/6088333 |
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