The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus

Diabetes mellitus (DM) is a fatal metabolic disease characterized by persistent hyperglycemia. In recent studies, mesenchymal stem cell (MSC)-derived exosomes, which are being investigated clinically as a cell-free therapy for various diseases, have gained attention due to their biomimetic propertie...

Full description

Saved in:
Bibliographic Details
Main Authors: Ju-El Kim, Jong-Won Lee, Gi Doo Cha, Jeong-Kee Yoon
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomimetics
Subjects:
Online Access:https://www.mdpi.com/2313-7673/10/1/49
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832589020014575616
author Ju-El Kim
Jong-Won Lee
Gi Doo Cha
Jeong-Kee Yoon
author_facet Ju-El Kim
Jong-Won Lee
Gi Doo Cha
Jeong-Kee Yoon
author_sort Ju-El Kim
collection DOAJ
description Diabetes mellitus (DM) is a fatal metabolic disease characterized by persistent hyperglycemia. In recent studies, mesenchymal stem cell (MSC)-derived exosomes, which are being investigated clinically as a cell-free therapy for various diseases, have gained attention due to their biomimetic properties that closely resemble natural cellular communication systems. These MSC-derived exosomes inherit the regenerative and protective effects from MSCs, inducing pancreatic β-cell proliferation and inhibiting apoptosis, as well as ameliorating insulin resistance by suppressing the release of various inflammatory cytokines. Consequently, MSC-derived exosomes have attracted attention as a novel treatment for DM as an alternative to stem cell therapy. In this review, we will introduce the potential of MSC-derived exosomes for the treatment of DM by discussing the studies that have used MSC-derived exosomes to treat DM, which have shown therapeutic effects in both type 1 and type 2 DM.
format Article
id doaj-art-faa6989c9f244a84b85fa4e1e2a3c775
institution Kabale University
issn 2313-7673
language English
publishDate 2025-01-01
publisher MDPI AG
record_format Article
series Biomimetics
spelling doaj-art-faa6989c9f244a84b85fa4e1e2a3c7752025-01-24T13:24:43ZengMDPI AGBiomimetics2313-76732025-01-011014910.3390/biomimetics10010049The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes MellitusJu-El Kim0Jong-Won Lee1Gi Doo Cha2Jeong-Kee Yoon3Department of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDiabetes mellitus (DM) is a fatal metabolic disease characterized by persistent hyperglycemia. In recent studies, mesenchymal stem cell (MSC)-derived exosomes, which are being investigated clinically as a cell-free therapy for various diseases, have gained attention due to their biomimetic properties that closely resemble natural cellular communication systems. These MSC-derived exosomes inherit the regenerative and protective effects from MSCs, inducing pancreatic β-cell proliferation and inhibiting apoptosis, as well as ameliorating insulin resistance by suppressing the release of various inflammatory cytokines. Consequently, MSC-derived exosomes have attracted attention as a novel treatment for DM as an alternative to stem cell therapy. In this review, we will introduce the potential of MSC-derived exosomes for the treatment of DM by discussing the studies that have used MSC-derived exosomes to treat DM, which have shown therapeutic effects in both type 1 and type 2 DM.https://www.mdpi.com/2313-7673/10/1/49diabetes mellitusmesenchymal stem cellsexosomestissue regeneration
spellingShingle Ju-El Kim
Jong-Won Lee
Gi Doo Cha
Jeong-Kee Yoon
The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
Biomimetics
diabetes mellitus
mesenchymal stem cells
exosomes
tissue regeneration
title The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
title_full The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
title_fullStr The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
title_full_unstemmed The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
title_short The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
title_sort potential of mesenchymal stem cell derived exosomes to treat diabetes mellitus
topic diabetes mellitus
mesenchymal stem cells
exosomes
tissue regeneration
url https://www.mdpi.com/2313-7673/10/1/49
work_keys_str_mv AT juelkim thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT jongwonlee thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT gidoocha thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT jeongkeeyoon thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT juelkim potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT jongwonlee potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT gidoocha potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus
AT jeongkeeyoon potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus