The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
Diabetes mellitus (DM) is a fatal metabolic disease characterized by persistent hyperglycemia. In recent studies, mesenchymal stem cell (MSC)-derived exosomes, which are being investigated clinically as a cell-free therapy for various diseases, have gained attention due to their biomimetic propertie...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomimetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-7673/10/1/49 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589020014575616 |
|---|---|
| author | Ju-El Kim Jong-Won Lee Gi Doo Cha Jeong-Kee Yoon |
| author_facet | Ju-El Kim Jong-Won Lee Gi Doo Cha Jeong-Kee Yoon |
| author_sort | Ju-El Kim |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a fatal metabolic disease characterized by persistent hyperglycemia. In recent studies, mesenchymal stem cell (MSC)-derived exosomes, which are being investigated clinically as a cell-free therapy for various diseases, have gained attention due to their biomimetic properties that closely resemble natural cellular communication systems. These MSC-derived exosomes inherit the regenerative and protective effects from MSCs, inducing pancreatic β-cell proliferation and inhibiting apoptosis, as well as ameliorating insulin resistance by suppressing the release of various inflammatory cytokines. Consequently, MSC-derived exosomes have attracted attention as a novel treatment for DM as an alternative to stem cell therapy. In this review, we will introduce the potential of MSC-derived exosomes for the treatment of DM by discussing the studies that have used MSC-derived exosomes to treat DM, which have shown therapeutic effects in both type 1 and type 2 DM. |
| format | Article |
| id | doaj-art-faa6989c9f244a84b85fa4e1e2a3c775 |
| institution | Kabale University |
| issn | 2313-7673 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj-art-faa6989c9f244a84b85fa4e1e2a3c7752025-01-24T13:24:43ZengMDPI AGBiomimetics2313-76732025-01-011014910.3390/biomimetics10010049The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes MellitusJu-El Kim0Jong-Won Lee1Gi Doo Cha2Jeong-Kee Yoon3Department of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDiabetes mellitus (DM) is a fatal metabolic disease characterized by persistent hyperglycemia. In recent studies, mesenchymal stem cell (MSC)-derived exosomes, which are being investigated clinically as a cell-free therapy for various diseases, have gained attention due to their biomimetic properties that closely resemble natural cellular communication systems. These MSC-derived exosomes inherit the regenerative and protective effects from MSCs, inducing pancreatic β-cell proliferation and inhibiting apoptosis, as well as ameliorating insulin resistance by suppressing the release of various inflammatory cytokines. Consequently, MSC-derived exosomes have attracted attention as a novel treatment for DM as an alternative to stem cell therapy. In this review, we will introduce the potential of MSC-derived exosomes for the treatment of DM by discussing the studies that have used MSC-derived exosomes to treat DM, which have shown therapeutic effects in both type 1 and type 2 DM.https://www.mdpi.com/2313-7673/10/1/49diabetes mellitusmesenchymal stem cellsexosomestissue regeneration |
| spellingShingle | Ju-El Kim Jong-Won Lee Gi Doo Cha Jeong-Kee Yoon The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus Biomimetics diabetes mellitus mesenchymal stem cells exosomes tissue regeneration |
| title | The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus |
| title_full | The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus |
| title_fullStr | The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus |
| title_full_unstemmed | The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus |
| title_short | The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus |
| title_sort | potential of mesenchymal stem cell derived exosomes to treat diabetes mellitus |
| topic | diabetes mellitus mesenchymal stem cells exosomes tissue regeneration |
| url | https://www.mdpi.com/2313-7673/10/1/49 |
| work_keys_str_mv | AT juelkim thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT jongwonlee thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT gidoocha thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT jeongkeeyoon thepotentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT juelkim potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT jongwonlee potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT gidoocha potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus AT jeongkeeyoon potentialofmesenchymalstemcellderivedexosomestotreatdiabetesmellitus |