Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy
Abstract Hyperthermia is an additional treatment method to radiation therapy/chemotherapy, which increases the survival rate of patients without side effects. Nowadays, Auroshell nanoparticles have attracted much attention due to their precise control over heat use for medical purposes. In this rese...
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| Format: | Article |
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Wiley
2023-02-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12107 |
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| author | Hadil M. Alahdal Sumya Ayad Abdullrezzaq Hawraz Ibrahim M. Amin Sitah F. Alanazi Abduladheem Turki Jalil Mehrdad Khatami Marwan Mahmood Saleh |
| author_facet | Hadil M. Alahdal Sumya Ayad Abdullrezzaq Hawraz Ibrahim M. Amin Sitah F. Alanazi Abduladheem Turki Jalil Mehrdad Khatami Marwan Mahmood Saleh |
| author_sort | Hadil M. Alahdal |
| collection | DOAJ |
| description | Abstract Hyperthermia is an additional treatment method to radiation therapy/chemotherapy, which increases the survival rate of patients without side effects. Nowadays, Auroshell nanoparticles have attracted much attention due to their precise control over heat use for medical purposes. In this research, iron/gold Auroshell nanoparticles were synthesised using green nanotechnology approach. Auroshell gold@hematite nanoparticles were synthesised and characterised with rosemary extract in one step and the green synthesised nanoparticles were characterised by X‐ray powder diffraction, SEM, high‐resolution transmission electron microscopy, and X‐ray photoelectron spectroscopy analysis. Cytotoxicity of Auroshell iron@gold nanoparticles against normal HUVEC cells and glioblastoma cancer cells was evaluated by 2,5‐diphenyl‐2H‐tetrazolium bromide method, water bath hyperthermia, and combined method of water bath hyperthermia and nano‐therapy. Auroshell gold@hematite nanoparticles with minimal toxicity are safe against normal cells. The gold shell around the magnetic core of magnetite caused the environmental and cellular biocompatibility of these Auroshell nanoparticles. These magnetic nanoparticles with targeted control and transfer to the tumour tissue led to uniform heating of malignant tumours as the most efficient therapeutic agent. |
| format | Article |
| id | doaj-art-faa0e58d73e94c128bd789575b8b5a00 |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-faa0e58d73e94c128bd789575b8b5a002025-02-03T06:47:17ZengWileyIET Nanobiotechnology1751-87411751-875X2023-02-01171223110.1049/nbt2.12107Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapyHadil M. Alahdal0Sumya Ayad Abdullrezzaq1Hawraz Ibrahim M. Amin2Sitah F. Alanazi3Abduladheem Turki Jalil4Mehrdad Khatami5Marwan Mahmood Saleh6Department of Biology College of Science Princess Nourah bint Abdulrahman University Riyadh Saudi ArabiaMedical Laboratory Techniques Department Al‐Maarif University College Beirut IraqDepartment of Chemistry College of Science Salahaddin University‐Erbil Erbil IraqDepartment of Physics College of Science Imam Mohammad Ibn Saud Islamic University Riyadh Saudi ArabiaDepartment of Medical Laboratories Techniques Al‐Mustaqbal University College Babylon, Hilla IraqAntibacterial Materials R&D Centre China Metal New Materials (Huzhou) Institute Huzhou Zhejiang ChinaDepartment of Biophysics College of Applied Sciences University of Anbar Ramadi IraqAbstract Hyperthermia is an additional treatment method to radiation therapy/chemotherapy, which increases the survival rate of patients without side effects. Nowadays, Auroshell nanoparticles have attracted much attention due to their precise control over heat use for medical purposes. In this research, iron/gold Auroshell nanoparticles were synthesised using green nanotechnology approach. Auroshell gold@hematite nanoparticles were synthesised and characterised with rosemary extract in one step and the green synthesised nanoparticles were characterised by X‐ray powder diffraction, SEM, high‐resolution transmission electron microscopy, and X‐ray photoelectron spectroscopy analysis. Cytotoxicity of Auroshell iron@gold nanoparticles against normal HUVEC cells and glioblastoma cancer cells was evaluated by 2,5‐diphenyl‐2H‐tetrazolium bromide method, water bath hyperthermia, and combined method of water bath hyperthermia and nano‐therapy. Auroshell gold@hematite nanoparticles with minimal toxicity are safe against normal cells. The gold shell around the magnetic core of magnetite caused the environmental and cellular biocompatibility of these Auroshell nanoparticles. These magnetic nanoparticles with targeted control and transfer to the tumour tissue led to uniform heating of malignant tumours as the most efficient therapeutic agent.https://doi.org/10.1049/nbt2.12107Auroshell nanoparticlescancer cellscore‐shellcore/shellgreen chemistryhyperthermia |
| spellingShingle | Hadil M. Alahdal Sumya Ayad Abdullrezzaq Hawraz Ibrahim M. Amin Sitah F. Alanazi Abduladheem Turki Jalil Mehrdad Khatami Marwan Mahmood Saleh Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy IET Nanobiotechnology Auroshell nanoparticles cancer cells core‐shell core/shell green chemistry hyperthermia |
| title | Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy |
| title_full | Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy |
| title_fullStr | Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy |
| title_full_unstemmed | Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy |
| title_short | Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy |
| title_sort | trace elements based auroshell gold hematite nanostructure green synthesis and their hyperthermia therapy |
| topic | Auroshell nanoparticles cancer cells core‐shell core/shell green chemistry hyperthermia |
| url | https://doi.org/10.1049/nbt2.12107 |
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